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Biophysical Sciences Institute

Conference Announcement

PROTEIN DYNAMICS AND FUNCTION

Durham University (Grey College)

April 15-17, 2013

This focussed conference will explore frontiers in experimental and theoretical understanding of biomolecular dynamics and the connection between dynamics and function.



Specific Topics Include:

  • Simulation at multiple length-scales
  • AFM, fluorescence, NMR and neutron methods for probing dynamics
  • Dynamics for protein function including allostery and catalysis

Accommodation and conference sessions will be at Collingwood College, Durham University, UK including a conference dinner in Durham Castle.  It is organised jointly between Durham University’s Biophysics Sciences Institute and FZ Jülich.  Bursaries for UK PhD students are available from the British Biophysical Society.



Timetable

Monday 15 April

10:30-12:00 Registration and welcome at Grey College
Session 1: Experimental techniques to study protein dynamics
14:00-14:35 Ralf Biehl (Jülich) "Large scale protein dynamics accessed by neutron spin echo spectroscopy"
14:35-15:10

Minoru Nakano (Univ. of Toyama) “Functional evaluation of a phospholipid transfer protein by Neutron Scattering”

15:10-15:30 Nicolas Martinez (Université Joseph Fourier) “Dynamical variants of Acetylcholinesterase
15:30-16:00 Martin Blackledge (Institut de Biologie Structurale) “Functionally Important Protein Conformational Dynamics on Multiple Timescales from Nuclear Magnetic Resonance Spectroscopy”
16:30-18:00 Poster session and drinks reception (Grey College, Holgate Room)
19:00 Dinner at Grey College

Tuesday 16 April

Session 2: Simulation at multiple length scales
09:00-09:35

Teresa Head-Gordon (Berkeley) “Statistical Fluctuations, Dynamics, and De Novo Enzyme Catalysis”

09:35-10:10 Robert Jernigan (Iowa State University) “Extracting Dynamics Information from Multiple Structures”
10:10-10:45 Coffee break
10:45-11:05 Gerhard Gompper (Jülich) “Domain motions in mercuric ion reductase merA: a perspective from mesoscale hydrodynamic simulations”
11:05-11:25

Igor Neelov (Russian Academy of Sciences) “Molecular Dynamics of Peptide Dendrimers”

11:25-11:45

Antoine Delmotte (Imperial College London) “Uncovering the organisation of protein structures at all scales using graph partitioning”

11:45-12:05

Sarah Harris (University of Leeds) “Modelling Biomacromolecules with Continuum Mechanics”

12:05-12:25 Steven Hayward (University of East Anglia) “The loop in liver alcohol dehydrogenase acts as a NAD+-activated switch for domain closure”
12:30-14:00

Lunch (Grey College)

Session 3: Allostery and catalysis
14:00-14:35 Amnon Horovitz (Weizmann) “Allostery in GroEL: mechanism and function”
14:35-15:10 Ivete Bahar (University of Pittsburgh) “Mechanism of Neurotransmitter Uptake by Glutamate Transporters: Learning from Theory, Computations and Experiments”
15:10-15:45 Coffee break
15:45-16:05

Andreas Stadler (Jülich) “Thermal Fluctuations of Haemoglobin from Different Species: Adaptation to Temperature via Conformational Dynamics”

16:05-16:25

Sarah Byrne (Imperial College London) “Protein kinases are involved in regulating diverse and essential cellular processes, and their dysfunction is implicated in many diseases, making kinases key drug targets.”

16:25-16:45 Robert Weinzierl (Imperial College London)
16:45-17:05 Martin Cann (Durham) “Global Low Frequency Protein Motions in the Allosteric Regulation of CRP/FNR family transcription factors”
17:05 Time for discussion
19:30 Dinner at the Durham Castle

Wednesday 17 April

Session 4: Experimental techniques to study protein dynamics 2
9:00-9:35 Alfonso De Simone (Imperial College London) Protein dynamics by NMR and simulations”
9:35-10:10 David Dryden (University of Edinburgh)
10:10-10:30 Tharin Blumenschein (University of East Anglia) “Solution structure and dynamics of a plant pathogen effector”
10:30-11:00 Coffee break
11:00-11:20 Dorothea Pinotsi (Cambridge University) “A label-free assay of amyloid fibril growth using intrinsic fluorescence”
11:20-11:40 Chris Forman (University of Cambridge) “Electron transport in amyloid: Three different kinds of dynamics in one system”
11:40-12:00 Gabriella Kaminski-Schierle (University of Cambridge) “In situ studies of protein aggregation kinetics with multiparametric and superresolution imaging”
12:00-12:20 Amit Sharma (University of Leeds) “Dance of the domains: Tracking large scale conformational dynamics in a molecular machine using single molecule techniques”
12:30 Closing Remarks (Tom McLeish)



Organising Committee: Tom McLeish, Ehmke Pohl (Durham); Dieter Richter, Ralf Biehl (Jülich)

To register please visit: https://www.dur.ac.uk/conference.booking/details/?id=164


Register for Protein Dynamics and Function

To register for this conference please visit the web page: www.dur.ac.uk/conference.booking/details/?id=164.

If you are experiencing problems with the registration website please email alex.probert@durham.ac.uk to register.

Conference e-Flyer