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Durham University

Department of Biosciences


Publication details for Dr Gary Sharples

Liotta, L.A., Medina, I., Robinson, J.L., Carroll, C.L., Pan, P.-S., Corral, R., Cook, K.M., Johnston, J.V.C., Curtis, F.A., Sharples, G.J. & McAlpine, S.R. (2004). Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions. Tetrahedron Letters 45: 8447-8450.

Author(s) from Durham


Described are the syntheses of 15 macrocyclic peptides designed to trap Holliday junctions(HJs) in bacteria during site-specific and homologous recombination. This leads to inhibiting bacterial growth. These second generation macrocycles were based on the C-2 symmetrical HJ. They were synthesized using a strategy that permits elucidation of the amino acid role in binding HJs. The syntheses of these macrocycles are an important step in the development of a new class of antibiotics.