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Durham University

Department of Biosciences

Profile

Publication details for Dr Gary Sharples

Bolt, Hannah L., Eggimann, Gabriela A., Jahoda, Colin A.B., Zuckermann, Ronald N., Sharples, Gary J. & Cobb, Steven L. (2017). Exploring the links between peptoid antibacterial activity and toxicity. MedChemComm 8(5): 886-896.

Author(s) from Durham

Abstract

Peptoids are a promising class of antimicrobial agents with reported activities against a range of both Gram-positive and Gram-negative bacteria, fungi and most recently parasites. However, at present the available toxicty data is somewhat limited and as such rationally designing effective antimicrobial peptoids can be challenging. Herein, we present the toxicity profiling of a series of linear peptoids against mammalian cell lines (HaCaT and HepG2). The cytotoxicity of the peptoid library has then been correlated with their antibacterial properties against Gram-positive and Gram-negative bacteria and also to the hydrophobicity of the peptoid sequences. The work presented provides valuable data to aid in the future rational design of antimicrobial peptoids.