Publication details for Dr Karrera DjokoMarsh, James W., Djoko, Karrera Y., McEwan, Alastair G. & Huston, Wilhelmina M. (2017). Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents. Pathogens and Disease 75(7): ftx084.
- Publication type: Journal Article
- ISSN/ISBN: 2049-632X (electronic)
- DOI: 10.1093/femspd/ftx084
- Further publication details on publisher web site
- Durham Research Online (DRO) - may include full text
Author(s) from Durham
Lipophilic copper (Cu)-containing complexes have shown promising antibacterial activity against a range of bacterial pathogens. To examine the susceptibility of the intracellular human pathogen Chlamydia trachomatis to copper complexes containing bis(thiosemicarbazone) ligands [Cu(btsc)], we tested the in vitro effect of CuII-diacetyl- and CuII-glyoxal-bis[N(4)-methylthiosemicarbazonato] (Cu(atsm) and Cu(gtsm), respectively) on C. trachomatis. Cu(atsm) and to a greater extent, Cu(gtsm), prevented the formation of infectious chlamydial progeny. Impacts on host cell viability and respiration were also observed in addition to the Chlamydia impacts. This work suggests that copper-based complexes may represent a new lead approach for future development of new therapeutics against chlamydial infections, although host cell impacts need to be fully explored.