Cookies

We use cookies to ensure that we give you the best experience on our website. You can change your cookie settings at any time. Otherwise, we'll assume you're OK to continue.

Durham University

Department of Biosciences

Profile

Publication details for Dr Tim R Blower

Cross, J.M., Blower, T.R., Kingdon, A.D.H., Pal, R., Picton, D.M. & Walton, J.W. (2020). Anticancer Ruthenium Complexes with HDAC Isoform Selectivity. Molecules 25(10): 2383.

Author(s) from Durham

Abstract

The histone deacetylase (HDAC) enzymes have emerged as an important class of molecular targets in cancer therapy, with five inhibitors in clinical use. Recently, it has been shown that a lack of selectivity between the 11 Zn-dependent HDAC isoforms may lead to unwanted side-effects. In this paper, we show that piano stool Ru complexes can act as HDAC inhibitors, and variation in the capping arene leads to differences in HDAC isoform selectivity.