Publication details for Dr Tim R BlowerCross, J.M., Blower, T.R., Kingdon, A.D.H., Pal, R., Picton, D.M. & Walton, J.W. (2020). Anticancer Ruthenium Complexes with HDAC Isoform Selectivity. Molecules 25(10): 2383.
- Publication type: Journal Article
- ISSN/ISBN: 1420-3049
- DOI: 10.3390/molecules25102383
- Further publication details on publisher web site
- Durham Research Online (DRO) - may include full text
Author(s) from Durham
The histone deacetylase (HDAC) enzymes have emerged as an important class of molecular targets in cancer therapy, with five inhibitors in clinical use. Recently, it has been shown that a lack of selectivity between the 11 Zn-dependent HDAC isoforms may lead to unwanted side-effects. In this paper, we show that piano stool Ru complexes can act as HDAC inhibitors, and variation in the capping arene leads to differences in HDAC isoform selectivity.