Publication details for Dr Rebecca ClarkClark, R.I., Woodcock, K.J., Geissmann, F., Trouillet, C. & Dionne, M.S. (2011). Multiple TGF-β superfamily signals modulate the adult Drosophila immune response. Current Biology 21(19): 1672-1677.
- Publication type: Journal Article
- ISSN/ISBN: 0960-9822 (print)
- DOI: 10.1016/j.cub.2011.08.048
- Further publication details on publisher web site
- Durham Research Online (DRO) - may include full text
Author(s) from Durham
TGF-β superfamily signals play complex roles in regulation of tissue repair and inflammation in mammals . Drosophila melanogaster is a well-established model for the study of innate immune function [2, 3] and wound healing [4–7]. Here, we explore the role and regulation of two TGF-β superfamily members, dawdle and decapentaplegic (dpp), in response to wounding and infection in adult Drosophila. We find that both TGF-β signals exhibit complex regulation in response to wounding and infection, each is expressed in a subset of phagocytes, and each inhibits a specific arm of the immune response. dpp is rapidly activated by wounds and represses the production of antimicrobial peptides; flies lacking dpp function display persistent, strong antimicrobial peptide expression after even a small wound. dawdle, in contrast, is activated by Gram-positive bacterial infection but repressed by Gram-negative infection or wounding; its role is to limit infection-induced melanization. Flies lacking dawdle function exhibit melanization even when uninfected. Together, these data imply a model in which the bone morphogenetic protein (BMP) dpp is an important inhibitor of inflammation following sterile injury whereas the activin-like dawdle determines the nature of the induced immune response.