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Durham University

Department of Biosciences

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Publication details for Dr P Chazot

Obara, Ilona, Telezhkin, Vsevolod, Alrashdi, Ibrahim & Chazot, Paul L. (2020). Histamine, histamine receptors and neuropathic pain relief. British Journal of Pharmacology 177(3): 580-599.

Author(s) from Durham

Abstract

Histamine, acting via distinct histamine H1, H2, H3 and H4 receptors (H1R, H2R, H3R, H4R), regulates various physiological and pathological processes, including pain. In the last two decades, there has been a particular increase in evidence to support the involvement of H3R and H4R in the modulation of neuropathic pain, that remains challenging in terms of management. However, recent data show contrasting effects on neuropathic pain due to multiple factors that determine the pharmacological responses of histamine receptors and their underlying signal transduction properties (e.g., localization on either the pre‐ or postsynaptic neuronal membrane). This review summarizes the most recent findings on the role of histamine and the effects mediated by the four histamine receptors in response to the various stimuli associated with and promoting neuropathic pain. We particularly focus on mechanisms underlying histamine‐mediated analgesia, as we aim to clarify the analgesic potential of histamine receptor ligands in neuropathic pain.