Publication details for Dr Martin SchröderM. Schröder (2008). Endoplasmic reticulum stress responses. Cellular and Molecular Life Sciences 65(6): 862-894.
- Publication type: Journal Article
- ISSN/ISBN: 1420-682X
- DOI: 10.1007/s00018-007-7383-5
- Further publication details on publisher web site
Author(s) from Durham
In homeostasis, cellular processes are in a dynamic equilibrium. Perturbation of homeostasis causes stress. In this review I summarize how perturbation of three major functions of the endoplasmic reticulum (ER) in eukaryotic cells-protein folding, lipid and sterol biosynthesis, and storing intracellular Ca2+ - causes ER stress and activates signaling pathways collectively termed the unfolded protein response (UPR). I discuss how the UPR reestablishes homeostasis, and summarize our current understanding of how the transition from protective to apoptotic UPR signaling is controlled, and how the UPR induces inflammatory signaling.