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School of Biological and Biomedical Sciences

Staff Profiles

Dr A Smertenko, PhD

Telephone: +44 (0) 191 33 41372
Room number: 1003


Career key points
1987 – 1992 – Undergraduate student at Kiev University, Ukraine;
1992-1996 – Researcher and part-time PhD student at the Institute of Cell Biology and Genetic Engineering , Kiev, Ukraine.
1994-1995 – Doctorate fellowships at the Institute of Molecular Genetic and Institute of Crop Production, Prague, Czech Republic.
1996-2000 – postdoctoral positions, Department of Biochemistry, Royal Holloway College, University of London, UK.
From Jan. 2001 – Senior Demonstrator, Department of Biological Sciences, Durham University, UK.

Indicators of Esteem

  • 2010: Speaker at Garnet Cells & Systems Meeting, Durham:
  • 2007: Invited Speaker at the North East Regional Life Sciences and Healthcare Network Bioimaging workshop:
  • 2005: Invited Speaker at the Meeting of British Society of Experimental Biology:

Research Interests

  • Live Cell Imagind and Fluorescence Microscopy
  • Microtubules and Actin Filaments
  • Plant Cell Biology
  • Plant Development
  • Programmed Cell Death

Selected Publications

Articles: review

Book chapters: online

Journal papers: academic

  • Banora M.Y., Rodiuc N., Baldacci-Cresp F., Smertenko A., Bleve-Zacheo T., Mellilo M.T., Karimi M., Hilson P., Evrard J.-L., Favery B., Engler G., Abad P. & de Almeida-Engler J. (2011). Feeding cells induced by phytoparasitic nematodes require gamma-tubulin ring complex for microtubule reorganization. PLoS Pathogens 7(12): e1002343.
  • Smertenko,A.P. , Piette,B. & Hussey,P.J. (2011). The origin of phragmoplast asymmetry. Current Biology 21(22): 1924-1930.
  • Smertenko A.P., Deeks M.J. & Hussey P.J. (2010). Strategies of actin reorganisation in plant cells. Journal of Cell Science 123: 3019-3029.
  • Smertenko, AP, Chang, HY, Sonobe, S, Fenyk, SI, Weingartner, M, Bogre, L & Hussey, PJ (2006). Control of the AtMAP65-1 interaction with microtubules through the cellcycle. Journal Of Cell Science 119(15): 3227-3237.
  • Oh, SA, Johnson, A, Smertenko, A, Rahman, D, Park, SK, Hussey, PJ & Twell, D (2005). A divergent cellular role for the FUSED kinase family in theplant-specific cytokinetic phragmoplast. Current Biology 15(23): 2107-2111.
  • Bozhkov, PV, Suarez, MF, Filonova, LH, Daniel, G, Zamyatnin, AA, Rodriguez-Nieto, S, Zhivotovsky, B & Smertenko, A (2005). Cysteine protease mcll-Pa executes programmed cell death during plant embryogenesis. Proceedings of the National Academy of Sciences of the United States of America 102(40): 14463-14468.
  • Suarez, MF, Filonova, LH, Smertenko, A, Savenkov, EI, Clapham, DH, von Arnold, S, Zhivotovsky, B & Bozhkov, PV (2004). Metacaspase-dependent programmed cell death is essential for plantembryogenesis. Current Biology 14(9): R339-R340.
  • Smertenko, AP, Chang, HY, Wagner, V, Kaloriti, D, Fenyk, S, Sonobe, S, Lloyd, C, Hauser, MT & Hussey, PJ (2004). The Arabidopsis microtubule-associated protein AtMAP65-1: Molecular analysis of its microtubule bundling activity. Plant Cell 16(8): 2035-2047.
  • Muller, S, Smertenko, A, Wagner, V, Heinrich, M, Hussey, PJ & Hauser, MT (2004). The plant microtubule-associated protein AtMAP65-3/PLE is essential for cytokinetic phragmoplast function. Current Biology 14(5): 412-417.
  • Bozhkov, PV, Filonova, LH, Suarez, MF, Helmersson, A, Smertenko, AP, Zhivotovsky, B & von Arnold, S (2004). VEIDase is a principal caspase-like activity involved in plantprogrammed cell death and essential for embryonic pattern formation. Cell Death And Differentiation 11(2): 175-182.
  • Chan, J, Mao, GJ, Smertenko, A, Hussey, PJ, Naldrett, M, Bottrill, A & Lloyd, CW (2003). Identification of a MAP65 isoform involved in directional expansion ofplant cells. Febs Letters 534(1-3): 161-163.
  • Smertenko, AP, Bozhkov, PV, Filonova, LH, von Arnold, S & Hussey, PJ (2003). Re-organisation of the cytoskeleton during developmental programmed cell death in Picea abies embryos. Plant Journal 33(5): 813-824.
  • Hussey, PJ, Allwood, EG & Smertenko, AP (2002). Actin-binding proteins in the Arabidopsis genome database: propertiesof functionally distinct plant actin-depolymerizing factors/cofilins. Philosophical Transactions Of The Royal Society Of London Series B-biological Sciences 357(1422): 791-798.
  • Patruno, M, Smertenko, A, Carnevali, MDC, Bonasoro, F, Beesley, PW & Thorndyke, MC (2002). Expression of transforming growth factor beta-like molecules in normaland regenerating arms of the crinoid Antedon mediterranea:immunocytochemical and biochemical evidence. Proceedings Of The Royal Society Of London Series B-biological Sciences 269(1502): 1741-1747.
  • Twell, D, Park, SK, Hawkins, TJ, Schubert, D, Schmidt, R, Smertenko, A & Hussey, PJ (2002). MOR1/GEM1 has an essential role in the plant-specific cytokineticphragmoplast. Nature Cell Biology 4(9): 711-714.
  • Allwood, EG, Anthony, RG, Smertenko, AP, Reichelt, S, Drobak, BK, Doonan, JH, Weeds, AG & Hussey, PJ (2002). Regulation of the pollen-specific actin-depolymerizing factor LIADF1. Plant Cell 14(11): 2915-2927.
  • Hussey, PJ, Hawkins, TJ, Igarashi, H, Kaloriti, D & Smertenko, A (2002). The plant cytoskeleton: recent advances in the study of the plantmicrotubule-associated proteins MAP-65, MAP-190 and the XenopusMAP215-like protein, MOR1. Plant Molecular Biology 50(6): 915-924.
  • Smertenko, AP, Allwood, EG, Khan, S, Jiang, CJ, Maciver, SK, Weeds, AG & Hussey, PJ (2001). Interaction of pollen-specific actin-depolymerizing factor with actin. Plant Journal 25(2): 203-212.
  • Allwood, EG, Smertenko, AP & Hussey, PJ (2001). Phosphorylation of plant actin-depolymerising factor by calmodulin-likedomain protein kinase. Febs Letters 499(1-2): 97-100.
  • Smertenko, A, Omran, MAA, Hussey, PJ & McVean, A (2001). Toxin evolution in scorpion venom: Evidence for toxin divergence understrong negative selection in Leiurus quinquestriatus subspecies. Journal Of Toxicology-toxin Reviews 20(3-4): 229-244.
  • Smertenko, A, Saleh, N, Igarashi, H, Mori, H, Hauser-Hahn, I, Jiang, CJ, Sonobe, S, Lloyd, CW & Hussey, PJ (2000). A new class of microtubule-associated proteins in plants. Nature Cell Biology 2(10): 750-753.
  • Hoa, NT, Baccigalupi, L, Huxham, A, Smertenko, A, Van, PH, Ammendola, S, Ricca, E & Cutting, SM (2000). Characterization of Bacillus species used for oral bacteriotherapy andbacterioprophylaxis of gastrointestinal disorders. Applied And Environmental Microbiology 66(12): 5241-5247.
  • Yemets, AI, Kundel'chuk, OP, Smertenko, AP, Solodushko, VG, Rudas, VA, Gleba, YY & Blume, YB (2000). Transfer of amiprophosmethyl resistance from a Nicotianaplumbaginifolia mutant by somatic hybridisation. Theoretical And Applied Genetics 100(6): 847-857.
  • Blume, YB, Strashnyuk, NM, Smertenko, AP, Solodushko, VG, Sidorov, VA & Gleba, YY (1998). Alteration of beta-tubulin in Nicotiana plumbaginifolia confersresistance to amiprophos-methyl. Theoretical And Applied Genetics 97(3): 464-472.
  • Smertenko, AP, Lawrence, SL & Hussey, PJ (1998). Immunological homologues of the Arabidopsis thaliana beta 1 tubulin arepolyglutamylated in Nicotiana tabacum. Protoplasma 203(3-4): 138-143.
  • Smertenko, AP, Jiang, CJ, Simmons, NJ, Weeds, AG, Davies, DR & Hussey, PJ (1998). Ser6 in the maize actin-depolymerizing factor, ZmADF3, isphosphorylated by a calcium-stimulated protein kinase and is essentialfor the control of functional activity. Plant Journal 14(2): 187-193.
  • Yemets, A, Kundelchuk, O, Smertenko, A & Blume, YB (1997). Cytoarchitecture of somatic hybrids of higher plants. Plant Physiology 114(3): 365-365.
  • Smertenko, A, Blume, Y, Viklicky, V & Draber, P (1997). Exposure of tubulin structural domains in Nicotiana tabacummicrotubules probed by monoclonal antibodies. European Journal Of Cell Biology 72(2): 104-112.
  • Smertenko, A, Draber, P, Viklicky, V & Opatrny, Z (1997). Heat stress affects the organization of microtubules and cell divisionin Nicotiana tabacum cells. Plant Cell And Environment 20(12): 1534-1542.
  • Smertenko, A, Blume, Y, Viklicky, V, Opatrny, Z & Draber, P (1997). Post-translational modifications and multiple tubulin isoforms inNicotiana tabacum L cells. Planta 201(3): 349-358.
  • Emets, AI, Blyum, YB, Smertenko, AP, Kundelchuk, OP, Rudos, VA & Gleba, YY (1997). The obtaining gamma-hybrids of higher plants with mutant beta-tubulin. Doklady Akademii Nauk 353(4): 557-561.
  • Emets, AI, Kundelchuk, OP, Smertenko, AP, Solodushko, VG, Blyum, YB & Gleba, YY (1996). Somatic hybrids of higher plants obtained fromamiprophosmethyl-resistant mutant Nicotiniana plumbaginifolia. Genetika 32(8): 1104-1111.
  • Strashnyuk, NM, Blume, YB, Smertenko, AP, Sidorov, VA & Gleba, YY (1993). The obtaining of amiprophosmethyl-resistant lines ofnicotiana-plumbaginifolia containing mutant tubulin. Doklady Akademii Nauk 332(2): 240-243.

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