Development and Regeneration
Group Coordinator: Dr. Carrie Ambler
Our Research Group studies how organisms develop from initial stem cells to early embryos to adulthood and how adult tissues are repaired and regenerated throughout an organism's life.
Embryo tissue development and adult tissue repair and regeneration are highly related processes; both rely on populations of stem cells or uncommitted precursor cells to undergo a highly-coordinated and step-wise programme of differentiation to produce the completed structure. The Development and Regeneration Research Group is an association of scientists with common interests in these two processes and how we can best apply our knowledge of normal, healthy development and regeneration to improve therapies for human diseases and pathologies. Although we are aligned to a common theme, the members of our group have varied research strengths in such areas as the regulation and differentiation of embryonic and tissue specific stem cells (e.g. epidermal, dermal, neural and cardiac stem cells), the genetic defects in familiar muscular dystrophy and the factors controlling skin and hair follicle development, maintenance and wound repair. Moreover, a core focus of this group is working to engineer new technologies need to provide improved solutions for regenerative therapy. Scientists in the Development and Regeneration Research Discussion Group are members of several University institutes and centres including the BSI, NESCI and Centre for Stem Cells and Regenerative Medicine.
- Dr Carrie A. Ambler
- Dr R Bashir
- Dr Martin Goldberg
- Dr N Hole
- Dr Paul Hunt
- Prof CAB Jahoda
- Dr Akis (Iakowos) Karakesisoglou
- Dr Arto Maatta
- Prof Stefan Przyborski
- Dr Martin Schröder
- Dr David Weinkove
Publications by staff in this group
Journal papers: academic
- Wojciechowicz, K., Gledhill, K., Ambler, C.A., Manning, C.B. & Jahoda, C.A.B. (2013). Development of the mouse dermal adipose layer occurs independently of subcutaneous adipose tissue and is marked by restricted early expression of FABP4. PLoS ONE 8(3): e59811.
- Lamb, R. & Ambler, C.A. (2013). Keratinocytes propagated in serum-free, feeder-free culture conditions fail to form stratified epidermis in a reconstituted skin model. PLoS ONE 8(1): e52494.
- Cabreiro, F., Au, C., Leung, K.-Y., Vergara-Irigaray, N., Cochemé, H.M., Noori, T., Weinkove, D., Schuster, E., Greene, N.D.E. & Gems, D. (2013). Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153(1): 228-239.
- Bell, E., Richardson, G.D., Jahoda, C., Phillips, H.M., Henderson, D., Owens, W.A. & Hole, N. (2012). Dermal stem cells can differentiate down an endothelial lineage. Stem Cells and Development 21(16): 3019-3030.
- Richardson, G.D., Breault, D., Horrocks, G., Cormack, S., Hole, N. & Owens, W.A. (2012). Telomerase expression in the mammalian heart. The FASEB Journal 26(12): 4832-4840.
- Boczonadi, Veronika & Määttä, Arto (2012). Annexin A9 is a periplakin interacting partner in membrane-targeted cytoskeletal linker protein complexes. FEBS Letters 586(19): 3090-3096.
- Virk, B, Correia, G, Dixon, DP, Feyst, I, Jia, J, Oberleitner, N, Briggs, Z, Hodge, E, Edwards, R, Ward, J, Gems, D & Weinkove, D (2012). Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model. BMC Biology 10: 67.
- Maltman, D.J, Brand, S, Belau, E, Paape, R, Suckau, D & Przyborski, S.A (2012). Top-Down Label-Free LC-MALDI analysis of the peptidome during neural progenitor cell differentiation reveals complexity in cytoskeletal protein dynamics and identifies progenitor cell markers. Stem Cells (30): 599-611.
- McInroy, Lorna & Maatta, Arto (2011). Plectin regulates invasiveness of SW480 colon carcinoma cells and is targeted to podosome-like adhesions in an isoform-specific manner. Experimental Cell Research 317(17): 2468-2478.
- Maltman, DJ, Brand, S, Belau, E, Paape, R, Suckau, D & Przyborski, SA (2011). Top-down label-free LC-MALDI analysis of the peptidome during neural progenitor cell differentiation reveals complexity in cytoskeletal protein dynamics and identifies progenitor cell markers. Proteomics 11(20): 3992-4006.
- Ambler, C. A. & Watt, F. M. (2010). Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of Jagged 1. Development 137(21): 3569-3579.
- Petukhova, L., Duvic, M. Hordinsky, M. Norris, D. Price, V. Shimomura, Y. Kim, H. Singh, P. Lee, A. Chen, W.V. Meyer, K.C. Paus, R. Jahoda, C.A., Amos, C.I. Gregersen, P.K. & Christiano, A.M. (2010). Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature 466(7302 ): 113-117.
- Cooke, MJ, Zahir, T, Phillips, SR, Shah, DSH, Athey, D, Lakey, JH, Shoichet, MS & Przyborski, SA (2010). Neural differentiation regulated by biomimetic surfaces presenting motifs of extracellular matrix proteins. Journal of Biomedical Materials Research Part A 93A(3): 824-832.
- Richardson, GD, Bazzi, H, Fantauzzo, KA, Waters, JM, Crawford, H, Hynd, P, Christiano, AM & Jahoda, CA (2009). KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin. Development 136(13): 2153-2164.
- Higgins, Claire A., Westgate, Gillian E. & Jahoda, Colin A. B. (2009). From telogen to exogen: mechanisms underlying formation and subsequent loss of the hair club fiber. Journal of Investigative Dermatology 129: 2100-2108.
- Croft, A.P. & Przyborski, S.A (2009). Mesenchymal stem cells expressing neural antigens instruct a neurogenic cell fate on neural stem cells. Experimental Neurology 216(2): 329-341.
- Breault DT, Min IM, Carlone, DL, Farilla, LG, Ambruzs, DM, Henderson, DE, Algra, S, Montgomery, RK, Wagers, AJ & Hole, N (2008). Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells. Proceedings of the National Academy of Sciences of the United States of America 105(30): 10420-10425.
- Stewart R, Yang C, Anyfantis G, Przyborski S, Hole N, Strachan T, Stojkovic M, Keith WN, Armstrong L & Lako M (2008). Silencing of the expression of pluripotent driven-reporter genes stably transfected into human pluripotent cells. Regenerative Medicine 3(4): 505-522.
- Wojciechowicz, K, Markiewicz, E & Jahoda CA (2008). C/EBPalpha identifies differentiating preadipocytes around hair follicles in foetal and neonatal rat and mouse skin. Experimental Dermatology 17(8): 675-680.
- Ojeh, Nkemcho, Pekovic, Vanja, Jahoda, Colin & Maatta, Arto (2008). The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation. Journal of Cell Science 121(16): 2705-2717.
- Christie, V. B., Barnard, J. H., Batsanov, A. S., Bridgens, C. E., Cartmell, E. B., Collings, J. C., Maltman, D. J., Redfern, C. P. F., Marder, T. B., Przyborski, S. & Whiting, A. (2008). Synthesis and evaluation of synthetic retinoid derivatives as inducers of stem cell differentiation. Journal of Organic & Biomolecular Chemistry 6(19): 3497-3507.
- Weinkove, D, Bastiani, M, Chessa, TAM, Joshi, D, Hauth, L, Cooke, FT, Divecha, N & Schuske, K (2008). Overexpression of PPK-1, the Caenorhabditis elegans Type I PIP kinase, inhibits growth cone collapse in the developing nervous system and causes axonal degeneration in adults. Developmental Biology 313(1): 384-397.
- Panbianco, C, Weinkove, D, Zanin, E, Jones, D, Divecha, N, Gotta, M & Ahringer, J (2008). A casein kinase 1 and PAR proteins regulate asymmetry of a PIP2 synthesis enzyme for asymmetric spindle positioning. Developmental Cell 15(2): 198-208.
- Maltman, DJ, Brand, S, Belau, E, Paape, R, Suckau, D & Przyborski, SA (2001). Top-down label-free LC-MALDI analysis of the peptidome during neural progenitor cell differentiation reveals complexity in cytoskeletal protein dynamics and identifies progenitor cell markers. Proteomics 20: 3992-4006.