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Durham University

Department of Biosciences

Academic Staff

Publication details for Dr Martin Goldberg

Goldberg, Martin W. (2017). Nuclear pore complex tethers to the cytoskeleton. Seminars in Cell & Developmental Biology 68: 52-58.

Author(s) from Durham

Abstract

The nuclear envelope is tethered to the cytoskeleton. The best known attachments of all elements of the cytoskeleton are via the so-called LINC complex. However, the nuclear pore complexes, which mediate the transport of soluble and membrane bound molecules, are also linked to the microtubule network, primarily via motor proteins (dynein and kinesins) which are linked, most importantly, to the cytoplasmic filament protein of the nuclear pore complex, Nup358, by the adaptor BicD2. The evidence for such linkages and possible roles in nuclear migration, cell cycle control, nuclear transport and cell architecture are discussed.