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Department of Biosciences

Academic Staff

Dr Paul Yeo, BSc (Hons), PhD

Telephone: +44 (0) 191 33 43982
Visiting Lecturer in the Department of Chemistry
Room number: 237, Centre for Bioactive Chemistry, Department of Chemistry, University Science Laboratories, South Road, Durham, DH1 3LE
Member of the Durham X-ray Centre
Lecturer in Microbiology (NME Strand Leader) in Phase 1 Medicine
Telephone: +44 (0) 191 33 40130
Telephone: +44 (0) 191 33 43982

Contact Dr Paul Yeo (email at r.p.yeo@durham.ac.uk)

Biography

Paul was appointed as Lecturer in Microbiology in 2004 after seven years working in the renowned Medical Research Council’s Virology Unit (Glasgow) as a senior scientist. Prior to that, he worked in the University of Reading on HIV. His current research interests are focussed on Respiratory Syncytial Virus (RSV) a major cause of respiratory disease in infants and the elderly. Throughout his research career Paul has focused upon the study of viral proteins for their structure, function and ultimately to use this information in the design of novel therapeutics. The results of this work will lead to a greater understanding of how viruses replicate and cause disease. He has identified potential targets for intervention particularly against the interaction between the RSV nucleocapsid and the polymerase. Further work on validating these targets as therapeutics is ongoing but they provide proof of principle that there are alternative strategies to be taken in the search for new reagents.

Current projects include:

•The assembly of Respiratory Syncytial Virus
•The interaction of Respiratory Syncytial Virus with the cytoskeleton
•The structure and function of the polymerase, its cofactors and the viral template

International Collaboration

  • James Crowe, Vanderbilt University, UAS

Research Groups

School of Biological and Biomedical Sciences

Wolfson Research Institute for Health and Wellbeing

Research Interests

  • Cell Biology
  • Membrane:Protein interactions
  • Molecular Biology
  • Structural Biology
  • Virology

Indicators of Esteem

  • 2012: Invited speaker, Wellcome Trust,' Understanding bottlenecks in the discovery of new therapie for Respiratory Syncytial Virus (RSV) infection: Invites to the Wellcome Trust New Frontiers meeting " Understanding bottlenecks in the discovery of new therapie for Respiratory Syncytial Virus (RSV) infection"
  • 2006: Invited Lecture, Cambridge: Invited to speak to Dept of Pathology, University of Cambridge Title "Sugar and spice and all things nice: A look at the internal proteins of the Mononegavirales"
  • 2006: Invited Lecture, Manchester: Invited to speak to the Dept of Chemistry, University of Manchester, Feb 2005. Title "The Inside story of negative-strand RNA viruses"
  • 2005: Invited Talk, JCUH, Middlesborough: Invited to speak to Dept of Pathology, JCUH Middlesbrough Title "RNA viruses in the Centre for Infectious Diseases"
  • 2001: Invited talk, Pfizer, Sandwich, Kent: Invited to speak to Virology Dept in Pfizer Title "Possible antiviral targets for Respiratory Syncytial virus"

Selected Publications

Journal Article

Show all publications