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Durham University

Research & business

Research lectures, seminars and events

The events listed in this area are research seminars, workshops and lectures hosted by Durham University departments and research institutes. If you are not a member of the University, but  wish to enquire about attending one of the events please contact the organiser or host department.


 

Chronobiological regulation of pulmonary disease

14th January 2021, 13:00, via Zoom, Dr John Blaikley, Manchester University, UK

Host: Steven O'Reilly

About the speaker: Prof John Blaikley is a lung transplant consultant and holds a prestigious MRC clinical scientist award- which are notoriously difficult to secure. His primary research is around the circadian regulation of inflammation and lung disease and around time of day in disease. He has published recently on the role of the circadian clock on wound healing and lung fibrosis in Science Translational Medicine and PNAS. John performs true translational research encompassing bedside to bench and back.

Abstract:

At the heart of chronobiology lies a circadian clock. This consists of a core set of transcripts that are regulated by a transcriptional translational feedback loop with a period of 24 hours. This “clock” temporally gates physiological and pathophysiological responses in the lung. Our work has shown how the clock regulates pulmonary infectious and inflammatory responses through alteration of Rho, NF-kappaB and AP-1 pathways in alveolar macrophages. It also regulates pulmonary fibrosis through temporal regulation of fibroblast behaviour via TBPL1 regulation of integrin beta 1. This temporal regulation explains circadian regulation of patient outcomes (including COVID-19) and permits discovery of novel therapeutic targets.

Contact steven.o'reilly@durham.ac.uk for more information about this event.

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