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Research

Research lectures, seminars and events

The events listed in this area are research seminars, workshops and lectures hosted by Durham University departments and research institutes. If you are not a member of the University, but  wish to enquire about attending one of the events please contact the organiser or host department.


 

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Events for 6 July 2018

Department of Chemistry: Mini-Symposium on boron-catalysed amidation: from theory to practice

10:00am, Musgrave Room

10.00 am Professor Henry Rzepa, Imperial College, London

Title: Computational catalysis: mechanistic reality checks.

Abstract: Computational chemistry can provide valuable reality checks for unravelling the mechanistic basis for catalytic processes. The process will be illustrated for reaction pathways of boron-based amidation catalysts and reagents, the use of calculated 11B NMR chemical shifts for helping to identify putative reaction intermediates and the publication of FAIR data archives as part of the scholarly publication processes.

10.30 am Dr Tom Sheppard, University College, London

Title: Borate esters as highly effective catalysts for direct amidation

Abstract: Simple borate esters such as B(OMe)3 and B(OCH2CF3)3 were found to very effective catalysts for mediating the direct amidation between carboxylic acids and amines. The reactions have an extremely wide substrate scope, and can be carried out very efficiently on large scale to produce multigram quantities of amide. The presentation will cover the development of this reaction, along with insights into the reaction mechanisms.

11.15 Coffee

11.45 Professor Kazuaki Ishihara, Nagoya University, Japan

Title: Rational design of high performance catalysts using boron Lewis acids

Abstract: We have studied on rational design of high performance catalysts based on acid–base combination chemistry. In this lecture, two topics will be focused. One is “Boronic Acid Catalysts for Dehydrative Condensation between Carboxylic Acids and Amines.”1 The other is “Boron Lewis Acid-assisted Chiral Brønsted Acid Catalysts for Enantioselective Cycloadditions.”2

References
1. (a) Wang, K.; Yanhui, Lu, Ishihara, K. to be submitted. (b) Yanhui, L.; Wang, K.; Ishihara, K. Asian J. Org. Chem. 2017, 6, 1111. (c) Ishihara, K.; Yanhui, L. Chem. Sci. 2017, 7, 1276.
2. (a) Hatano, M.; Sakamoto, T.; Ishihara, K. to be submitted. (b) Sakamoto, T.; Mochizuki, T.; Goto, Y.; Hatano, M.; Ishihara, K. Chem. Asian J. 2018, 13, in press. (c) Hatano, M.; Hayashi, K.; Sakamoto, T.; Makino, Y.; Ishihara, K. Synlett 2016, 27, 1061. (d) Hatano, M.; Ishihara, H.; Goto, Y.; Ishihara, K. Synlett 2016, 27, 564. (e) Hatano, M.; Goto, Y.; Izumiseki, A.; Akakura, M.; Ishihara, K. J. Am. Chem. Soc. 2015, 137, 13472. (f) Hatano, M.; Mizuno, T.; Izumiseki, A.; Usami, R.; Asai, T.; Akakura, M.; Ishihara, K. Angew. Chem. Int. Ed. 2011, 50, 12189.

12.45 Buffet lunch