Cookies

We use cookies to ensure that we give you the best experience on our website. You can change your cookie settings at any time. Otherwise, we'll assume you're OK to continue.

Research

Research lectures, seminars and events

The events listed in this area are research seminars, workshops and lectures hosted by Durham University departments and research institutes. If you are not a member of the University, but  wish to enquire about attending one of the events please contact the organiser or host department.


 

June 2018
SunMonTueWedThuFriSat
May 2018 July 2018
1 2
3 4 5 6 7 8 9
10 11 12 13 14 15 16
17 18 19 20 21 22 23
24 25 26 27 28 29 30

Events for 4 June 2018

Chris Prior: Some statistical/probabilistic questions regarding protein structure identification

2:00pm, CM221

Together with Ehmke Pohl of the Durham structural biology unit I have developed a novel technique for predicting protein structures from small angle scattering data (SAXS). SAXS is a technique where x-rays are fired at a sample of protein in solution, close to its natural environment. It is the technique with by far the most potential use, but also the hardest to interpret due to the random motion of the protein in solution. This makes the scattering data much more noisy than usual and also means a huge amount of information is lost. I will review the technique which uses a novel curve representation to fit a model to data. The potential models are drawn from a set of probability distributions which have been empirically obtained and are highly unusual. There are a series of questions concerning 1). Smoothing the noise in the experimental data which the model is fitted to. 2) Determining the shape of the parameter space of potential structures, 3) building in extra uncertainty in the model. I have reached the limit of my rudimentary knowledge in this field and need your help! I will try to get you enthused about the project in this talk.

Contact sunil.chhita@durham.ac.uk for more information about this event.