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Department of Mathematical Sciences

Seminar Archives

On this page you can find information about seminars in this and previous academic years, where available on the database.

Biomathematics Seminar: Large deviations in Markov State Models of protein-folding

Presented by Dr Rob Jack, Bath University

25 February 2014 14:00 in Department of Mathematical Sciences

Protein-folding is a complex and co-operative dynamical
process. For a variety of proteins, Markov state models with up to a
few thousand states can be inferred from computer simulation data: these
models give useful descriptions of the folding process. We use large
deviation methods to bias the dynamical evolution of these models,
leading to states where conformational motion may be suppressed or
enhanced. This allows some generic aspects of protein folding to be
identified. The states where motion is rare are also implicated in
protein misfolding.

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