Biomathematics Seminar: Structure of a Non-specific endonuclease-inhibitor complex reveals insight for drug development
25 February 2011 15:15 in CM107 (Mathematical Sciences)
Nonspecific, extracellular nucleases have received enhanced attention recently as a consequence of the critical role that these enzymes can play in infectivity by overcoming the human host neutrophil defense system. The neutrophil defense system in humans called Neutrophil Extracellular Traps (NETs) are to fight against foreign infection. The structural insights of the -cyanobacterial non-specific nuclease NucA and its complex with the specific protein inhibitor NuiA, shows clearly how its activity is controlled by the inhibitor NuiA. . The structure of cyanobacterial nuclease inhibitor complex provides valuable insights for the designing and development of inhibitors of its related nucleases. The related nonspecific nucleases that share the same active site motif similar to NucA are the /Streptococcus pneumoniae/ nuclease EndA, or /Serratia marcescens/ nuclease named Serratia nuclease, both of which mediates infectivity of the pathogen.