Numerical Analysis Seminars: Modelling Cerebrospinal Fluid Dynamics
29 October 2010 14:15 in CM105
Cerebrospinal fluid (CSF) is a water like substance produced from blood
by an active pumping mechanism at a number of sites in the brain but
particularly in ventricles near the centre. CSF mostly flows through a channel system to the outside of the brain and around the spinal chord where it is absorbed into a large vein, the superior sagittal sinus. The extent to which CSF also flows through the
brain tissue (parenchyma) is not certain. We have modelled the brain
parenchyma as a poroelastic material where flow and elastic deformation interact so as to provide a spatially varying, time dependent model of the CSF movement from the ventricles
to the superior sagittal sinus. We have used this model to study hydrocephalus (a long time scale process) and and most recently, shorter time scale dynamics of what is called
an infusion test where the CSF production rate is artificially and
temporarily increased for a period of 15-20 minutes by saline injection directly into the CSF system (what
engineers might call a step test). For this later model we have developed a
multi-fluid compartment version of the usual one fluid poroelastic framework.
In this talk I will outline our work, both model development and our
attempts to compare simulation with clinical data.
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