Biomathematics Seminar: Quantitative analysis of non-linear chromosome oscillations in mitosis
15 October 2010 15:15 in CM107 (Mathematical Sciences)
During cell division chromosomes undergo large excursions (ranging up to several microns) from the centre of the cell towards the poles with uniform velocity punctuated by abrupt changes in direction. Such oscillatory motion has been termed "directional instability'' and is crucial in segregating genetic material into daughter cells. Despite several experimental and theoretical attempts an understanding of this phenomenon is still lacking. I will propose a simple model based on interactions between microtubules and chromosomes which explains the behaviour of mitotic chromosomes. It is seen from experiments that cancer suppressing drugs change the nature of microtubule dynamics and chromosome oscillations. I will describe how our model and time series analysis can be used to test efficacies of such drugs.