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Department of Mathematical Sciences

Seminar Archives

On this page you can find information about seminars in this and previous academic years, where available on the database.

Statistics Seminars: Stochastic Modelling and Simulation Regimes for Gene Regulation

Presented by Des Higham , Department of Mathematics University of Strathclyde, Glasgow

19 April 2010 14:15 in CM221

The framework of chemical kinetics is now widely used to model activities taking place in the cell. In cases where some species are present at low copy numbers, discrete stochastic modelling is appropriate. However, for reasons of computational efficiency, multi-scale or `hybrid' models that incorporate real-valued stochastic or even deterministic components are attractive.
I will consider two very simple scenarios where analytical insights are possible. First, focusing on mean exit times, I will study the extent to which a real-valued diffusion (Langevin) process can approximate a discrete birth-and-death (Gillespie) process. Second, I will look at a few basic transcription/translation models in gene regulation, including some with feedback loops. Here the effects of mixing and matching modelling regimes can also be quantified.

Host: Umberto Picchini

Contact sunil.chhita@durham.ac.uk for more information