Our Research Community
The Biophysical Sciences Institute is a community of excellent interdisciplinary academics.
People
Professor Carrie Ambler, Department of Biosciences & LightOX
Areas of Expertise: Animal Cells and Systems
Research Interests: Collaborative, multi-disciplinary approaches to tackling wound repair, cancer and antimicrobial resistance.
Dr Ander Andershorst-Roberts, Department of Physics
Areas of Expertise: Soft Matter Physics
Research Interests
- Rheology
- Microrheology
- Assembly and Mechanics of Cytoskeletal Networks
- Biopolymers
- Hydrogels
Professor Colin Bain, Department of Chemistry
Areas of Expertise: Complex Fluids and Interfaces
Research Interests
- Colloid and interface science
- Inkjet printing of functional films
- Fundamentals and applications of droplet drying
Dr Robert Banks, Department of Biosciences
Areas of Expertise: Neurobiology, Structure and Function of Sensory Receptors in Muscle
Research Interests
- Mechanosensory transduction
- The role of synaptic-like vesicles in the sensory endings of mechanoreceptors
- The roles and importance of mitochondria in mechanosensory nerve endings, and why they are so abundant in them
Dr Aakash Basu, Department of Biosciences
Areas of Expertise: Biomolecular Interactions, Genomics, Single-molecule Biophysics
Research Interests
- Deciphering the mechanical code of the genome and epigenome
- Understanding how sequence-encoded mechanical properties of DNA encode regulatory information
Dr Ulrike Bechtold, Department of Biosciences
Areas of Expertise: Plant Cell Biology
Research Interests
- Plant stress responses
- Signalling pathways
- Transcriptional and post-transcriptional regulation
- Post-translational modifications
- Comparative genomics
- Evolution of genomes and quantitative trait architecture
Dr Ulrik Beierholm, Department of Psychology
Areas of Expertise: Computational Neuroscience
Research Interests: How the nervous system deals with uncertainty, whether in perception, decision making or learning.
Professor Adam Benham, Department of Biosciences
Areas of Expertise: Cell Biology, Biochemistry, Immunology
Research Interests
- Oxidative folding of secretory proteins in the Endoplasmic Reticulum
- Protein chaperone function
- Antigen processing and presentation by the immune system
Dr Alessandro Borghi, Department of Engineering
Area of Expertise: Biomedical Engineering, Biomechanics
Research Interests
- Biomechanics
- Finite Element Analysis
- Biological Tissue Characterisation
- Biomaterials
- Medical Image Processing
- Surgical planning
- Medical Devices
- Machine Learning
Dr Stefan Borsley, Department of Chemistry
Area of Expertise: Supramolecular Chemistry, Nonequilibrium Systems
Research Interests
- Nonequilibrium chemistry
- Ratchet mechanisms
- Compartmentalisation
- Gradient-driven systems
Dr Francesco Boselli, Departments of Biosciences and Engineering
Areas of Expertise: Bioengineering and Biological Physics
Research Interests
- Biological Fluid Mechanics
- Tissue Mechanics
- Mechanotransduction
- Live Imaging
- Cilia; Embryonic Heart; Inner Ear
Professor Martin Cann, Department of Biosciences
Areas of Expertise: Biochemistry
Research Interests
- Carbon dioxide sensing
- Bacterial death
Dr Paul Chazot, Department of Biosciences & Nevrargenics
Areas of Expertise: Neuroscience, Chronic Pain, Pharmacology
Research Interests: Identifying and validating novel drug targets and prodromal bio- and behavioural-markers for a range of common chronic neurological and metabolic pathologies.
Dr Peter Chivers, Department of Biosciences
Areas of Expertise: Bioinorganic Chemistry
Research Interests: Molecular determinants of microbial metal homeostasis.
Professor Steven Cobb, Department of Chemistry
Areas of Expertise: Synthetic Chemistry, Peptoid and Peptide Chemistry
Research Interests
- Peptide and peptoid chemistry
- Antimicrobials
- Anticancer
- Bio-organic fluorine chemistry
Dr Vincent Croset, Department of Biosciences
Areas of Expertise: Neurobiology, (Single-cell) Transcriptomics, Behaviour
Research Interests: Effects of nutritional state and drugs of abuse on neuronal physiology, gene expression and behaviour.
Dr Timothy Davies, Department of Biosciences
Areas of Expertise: Cell Division
Research Interests
- Variation in cell division requirements
- elegans development
- Cytoskeletal structure and dynamics
Dr Jingjing Deng, Department of Computer Science
- BioMedical Image Analysis
- Computer Vision
- Deep Neural Networks
- Machine Learning
Professor Paul Denny, Department of Biosciences
Areas of Expertise: Cell Biology, Parasitology, Lipid Biochemistry
Research Interests
- Protozoan sphingolipid biosynthesis
- Antileishmanial therapeutic discovery
- Antileishmanial mode of action deconvolution
- Molecular diagnostics for protozoan infections
Dr Karrera Djoko, Department of Biosciences
Areas of Expertise: Metals in Biology
Research Interests
- The impact of metal availability on microbial physiology
- How microbes respond to changing metal availability
- How host organisms influence metal availability to host-associated microbes
Dr David Doupé, Department of Biosciences
Areas of Expertise: Stem Cells, Developmental Biology, Genetics, Drosophila melanogaster
Research Interests
- Epithelial stem cell regulation
- Stem cell live intravital imaging
- Epithelial homeostasis and ageing
Professor Suzanne Fielding, Department of Physics
Areas of Expertise: Soft Condensed Matter Physics
Research Interests
- Flow instabilities and flow-induced phase transitions
- Fluid-fluid demixing
- Viscoelastic turbulence
- Soft glassy rheology
- Biologically active suspensions
Dr Allegra Franchino, Department of Chemistry
Area of Expertise: Catalysis, Synthetic Chemistry, Mechanistic Studies, Bioactive Chemistry
Research Interests
- Merging transition-metal and organocatalysis for selective synthesis
- Asymmetric catalysis targeting bioactive compounds, carbo- and heterocycles
- Design of bifunctional ligands and catalysts
- Non-covalent interactions and supramolecular systems
- Mechanistic studies of catalytic reactions (kinetics, modern physical organic chemistry, NMR spectroscopy)
Dr Lian Gan, Department of Engineering
Areas of Expertise: Fluid Mechanics, Vortex Dynamics
Research Interests
- Pulsatile and periodic flows
- Vortex dynamics in cardiovascular system
- Flow structure interaction in cardiovascular system
- 4D flow MR
Professor John Girkin, Department of Physics
Areas of Expertise: Advanced Photonics and Optical Technologies
Research Interests
- Advanced optical microscopy
- Development of microfluidic technologies to study biological systems
- Developing novel non-invasive tools for diagnosis
Dr Tim Hawkins, Department of Biosciences
Areas of Expertise: Molecular Cell Biology
Research Interests
- Combining high-resolution imaging with mechanical manipulation and modelling in both animal and plants cells
- Characterisation of members of the NET family of plant actin binding proteins which link the actin cytoskeleton to district membrane compartments
Dr Sarah Heaps, Department of Mathematical Sciences
Areas of Expertise: Bayesian Modelling and Inference, Bayesian Time-series Analysis
Research Interests
- multivariate time-series modelling of neuroscience data
- stochastic modelling of time-course metagenomic data
- statistical modelling of crystallization outcomes
Professor Jonathan Heddle, Department of Biosciences
Areas of Expertise: Bionanoscience and Biochemistry
Research Interests
- Design and assembly of artificial protein nanostructures
- Natural nanomachines: Investigation of topoisomerases, specifically DNA gyrase
- Development of DNA-based programmable nanomachines
- Aging
Professor David Hodgson, Department of Chemistry
Areas of Expertise: Physical Organic Chemistry, Synthetic Chemistry.
Research Interests
- Nucleosides and Nucleotides
- Fluorination
- Understanding Reactivity through Kinetics
- Bioconjugation
Dr Ostap Hryniv, Department of Mathematical Sciences
Areas of Expertise: Probability and Stochastic Processes
Research Interests
- Phase transitions
- Interacting particle systems
- Large deviations
- Stochastic modelling
Professor Colin Jahoda, Department of Biosciences
Areas of Expertise: Developmental Biology; Animal Cells and Systems, Stem Cells
Research Interests
- Adult hair growth and skin wound healing
- Skin regeneration and replacement
- Production of 3D in vitro skin and cornea models
- Transdifferentiation of epithelial stem cells
- Human hair follicle induction
Dr Rahele Kafieh, Department of Engineering
Areas of Expertise: Biomedical image and signal processing, Artificial Intelligence
Research Interests
- Medical Data Analysis
- Machine learning / Deep Learning
- Image Processing and Computer Vision
- Data Acquisition and Management
- Time-frequency methods
- Dictionary learning
- Data Quality Assessment
Dr Akis (Iakowos) Karakesisoglou, Department of Biosciences
Areas of Expertise: Animal Cell Biology, Disease
Research Interests
- Linker of the Nucleoskeleton and Cytoskeleton complex (LINC) cell biology
- The role of the cytoskeleton and spectrin-family of proteins in cell architecture and disease
- Breast cancer and skin mechanobiology
- Breast cancer diagnostics
- Premature (HGPS) and physiological human ageing (emphasis on skin and epithelial cell biology [RPE, Hepatocyte, breast, intestine])
- Laminopathies, nesprinopathies, muscle disorders, motor neuron disease (ALS) and Alzheimer’s
Professor Ritu Kataky, Department of Chemistry
Areas of Expertise: Electrochemistry, Sensors
Research Interests
- Developing sensors and biosensors for environmental, clinical and pharmaceutical monitoring
- Detection and Destruction of Biofilms on soft and hard surfaces
Dr Ciara Keating, Department of Engineering
Area of Expertise: Microbiology, Microbial Ecology, Environmental Engineering, Biotechnology, Bioinformatics
Research Interests
- Environmental Microbiology
- Molecular Biology and ‘Omics methods
- Soil and Plant Health
- Waste Treatment Systems
- Anaerobic microbiology
Professor Ashraf Khir, Department of Engineering
Areas of Expertise: Physiological Fluid Mechanics, Artificial Hearts/ Ventricular Assist Devices (VAD).
Research Interests
- Arterial waves
- Arterial stiffness – wave speed - PWV
- Non-invasive physiological hemodynamic ultrasound measurements
- Wave intensity analysis (WIA)
- Arterial wall mechanics
- Intra-Aortic Balloon Pump (IABP)
- Design of continuous and pulsatile flow blood pumps
- Mock circulatory loops
Dr Matthew Kitching, Department of Chemistry
Areas of Expertise: Synthetic Chemistry, Supramolecular Chemistry & Functional Molecules
Research Interests
- Enantioselective Synthesis of Chiral Ammonium Centres
- Smart droplets
Professor Heather Knight, Department of Biosciences
Areas of Expertise: Molecular Plant Cell Biology
Research Interests
- The roles of genes in the model plant Arabidopsis thaliana that determine the plant’s level of tolerance to freezing stress
- Physical and mechanical properties of plants that determine freezing resistance
Professor Marc Knight, Department of Biosciences
Areas of Expertise: Plant Molecular Cell Biology, Plant Signalling
Research Interests: How stress information is encoded in calcium responses and how this is decoded by plants to produce the appropriate survival response.
Dr Andrew Krause, Department of Mathematical Sciences
Areas of Expertise: Mathematical and Computational Modelling
Research Interests
- Pattern formation in developmental biology
- Reaction-diffusion systems
- Spatial population dynamics
- Nonlinear dynamical systems
Dr Alison Lane, Department of Psychology
Areas of Expertise: Clinical Neuropsychology
Research Interests
- Concussion / sub-concussive head impacts
- Neurorehabilitation
- Visuospatial attention
Dr Ting-Yu Lin, Department of Biosciences
Areas of Expertise: Structural Biology, Biochemistry, Molecular Biology
Research Interests
- Structural and biochemical analyses of pseudouridine synthases
- RNA modification
- RNA Biology
Professor Keith Lindsey, Department of Biosciences
Areas of Expertise: Plant Molecular Cell Biology, Plant Signalling
Research Interests: Identification of plant intracellular signalling molecules - roots and development
Dr Junli Liu, Department of Biosciences
Areas of Expertise: Systems biology
Research Interests: Hormone and Calcium Signalling in Plants.
Dr Clare Mahon, Department of Chemistry
Areas of Expertise: Polymer Chemistry, Molecular Recognition, Biological Chemistry
Research Interests
- Development of sensors and diagnostics for bacterial disease
- Design of polymeric materials for use in biomedicine
- Improving understanding of biodegradation
Professor Alistair McGregor, Department of Biosciences
Areas of Expertise: Evolutionary Developmental Biology, Animal Cells and Systems
Research Interests
- Genetic regulation of development,
- Morphological evolution in animals,
- Genome evolution and duplicated gene fate,
- The evolution and specificity of Wnt ligands
Dr Jonathon McPhetres, Department of Psychology
Areas of Expertise: Psychophysiology, Systems Biology
Research Interests: Using biological models to understand social behaviours and higher levels cognitions.
Dr Liz Morris, Department of Biosciences
Areas of Expertise: Structural biology, Biophysics, Biochemistry, Virology
Research Interests
- Enzyme mechanisms
- Protein-protein and protein-nucleotide interactions involved in virus replication
Dr Billy Moses Jr., Department of Computer Science
Area of Expertise: Theoretical foundations of distributed computing
Research Interests
- Distributed algorithms
- Biologically inspired computing
- Peer to Peer networks
- Movement and computing, especially involving mobile agents on a graph
Dr Patricia Muller, Department of Biosciences
Areas of Expertise: Biochemistry, Metalloproteins, p53, Cancer, Cell Engulfment
Research Interests
- Role of metals in regulating p53 function
- Mutant p53 function in cancer
Professor Marko Nardini, Department of Psychology
Areas of Expertise: Visual and multisensory perception
Research Interests
- Perceptual and Cognitive development
- Perception with New Sensory Signals
Professor AnnMarie O'Donoghue, Department of Chemistry
Areas of Expertise: Physical Organic Chemistry, Catalysis, Synthesis, Kinetics and mechanism, Kinetic acidity and pKa determination
Research Interests
- Synthetic organocatalysis and biocatalysis
- Mechanistic studies of organocatalysis and biocatalysis
- Enzyme mechanisms
- Synthesis and applications of stable organic radicals
Dr Lars-Olof Pålsson, Department of Chemistry
Areas of Expertise: Chemical physics, Biophysics
Research Interests
- Sensing surfaces based on fluorescent Langmuir-Blodgett films
- Electronic energy transfer in photosynthetic systems
Professor Bernard Piette, Department of Mathematical Sciences
Areas of Expertise: Mathematical Physics and Biophysics
Research Interests
- Mathematical modelling of biological systems
- Geometries of nano-bio-materials
- Electron-phonon interaction in nano-systems
Dr Denis Patterson, Department of Mathematical Sciences
Area of Expertise: Nonlinear Dynamics, Stochastic Analysis, and Mathematical Modelling
Research Interests
- Mathematical Ecology: Vegetation Models
- Mathematical Modelling: Developmental Biology
- Mathematical Epidemiology: Malaria
Professor Ehmke Pohl, Departments of Biosciences and Chemistry & Nevrargenics
Areas of Expertise: Structural Biology
Research Interests
- Structure-based drug design focusing in infectious diseases
- High-throughput screening for drug discovery
Dr Christopher Prior, Department of Mathematical Sciences
Areas of Expertise: Magnetohydrodynamics, Topological Constraints
Research Interests
- Magnetohydrodynamics
- Solar physics
- Protein dynamics
- Biological filament elasticity and topological constraints
Professor Stefan Przyborski, Department of Biosciences & Reprocell
Areas of Expertise: Bioengineering Human Tissues, Development and Translation of Advanced Cell Technologies, Cell and Tissue Differentiation in Health and Disease, 3Rs – Developing Alternatives for Animals in Research
Research Interests
- Human cell culture and building tissue equivalents
- Design and application of cell culture plasticware
- Bioreactor development and construction
- Device design and prototyping
- Cell and tissue differentiation methods
- Cell / tissue imaging and molecular analysis
- Commercialisation of technology and company development/operation
- Working at the industrial interface
Dr Susan Pyner, Department of Biosciences
Areas of Expertise: Signalling and Animal Cell Systems
Research Interests
- Autonomic regulation and neuroanatomy
- Tracing studies and immunocytochemical analysis of brain regions involved in cardiovascular homeostasis
Dr Lena Riabinina, Department of Biosciences
Areas of Expertise: Neuroscience, Genetics, Sensory Ecology
Research Interests
- Mosquito olfactory neurobiology
- Mosquito vision
- Evolution of chemical signals in mosquitoes
- Bumblebee olfactory neurobiology and ecology
- Olfaction of Black soldier flies
- Development of genetic tools for insects
Professor Ari Sadanandom, Department of Biosciences
Areas of Expertise: Molecular Plant Sciences
Research Interests: Polypeptide tags: Protein Modification systems such as Small Ubiquitin-like MOdifiers (SUMO) and their roles in plants' resilience under a changing climate.
Dr Rebecca Senior, Department of Biosciences
Areas of Expertise: Conservation, Ecology, Quantitative Tools & Technology
Research Interests: The use of quantitative tools and technology to understand the drivers of biodiversity loss.
Dr Gary Sharples, Department of Biosciences
Areas of Expertise: Microbiology, Biochemistry, Molecular Biology
Research Interests
- Antibacterial mechanism of action of chelating agents, clay minerals, antibacterial surfaces and other novel antibacterial compounds.
- Bacteriophage recombinases
Dr Margarita Staykova, Department of Physics
Areas of Expertise: Biophysics, Biological Membranes, Functional Interfaces, Living Materials
Research Interests
- The mechano-sensitive architecture and composition of the cell interface
- Cell-cell adhesion, encapsulation
- Bio-hybrid systems
- Bacterial growth
Professor Patrick Steel, Department of Chemistry
Areas of Expertise: Synthetic Chemistry, Chemical Biology
Research Interests
- Synthesis and Application of Boronic Acids
- Fragment based Drug Discovery
- Chemical Probes
- plant chemical biology - plant hormonal signalling pathways and crop protection agents
- Parasite chemical biology: leishmaniasis and T. cruzi
Professor Anne Taormina, Department of Mathematical Sciences
Areas of Expertise: Biological Applications of Mathematics
Research Interests
- Group theory and applications to mathematical biology
- String and conformal field theory
Dr Lore Thaler, Department of Psychology
Areas of Expertise: Human Psychophysics, Psychoacoustics, Functional Magnetic Resonance Imaging (fMRI)
Research Interests
- Sensory neuroplasticity
- Blindness
- Human echolocation
Dr Adam Townsend, Department of Mathematical Sciences
Areas of Expertise: Applied & Computational Mathematics, Mathematical Biology
Research Interests
- Development of mathematical and computational techniques to investigate complex fluids
- Non-Newtonian fluid mechanics
Professor Kislon Voitchovsky, Department of Physics
Areas of Expertise: Biological Physics, Experimental Soft Matter
Research Interests
- Solid-liquid and soft interfaces at the nanoscale
- Interfacial phenomena
- Ionic effects
- Emergence of mesoscale order
Dr David Weinkove, Department of Biosciences & Magnitude Biosciences
Areas of Expertise: Animal Cells and Systems, Ageing, Microbiome, Automated Analysis of Ageing
Research Interests: Study of the nematode worm Caenorhabditis elegans to gain insights into basic biological processes such as ageing and host:microbe interactions.
Professor Darren Wilkinson, Department of Mathematical Sciences
Area of Expertise: Bayesian Statistical Inference and Computational Systems Biology
Research Interests
- Computational approaches to inference and inverse problems
- Molecular systems biology modelling and inference
- Stochasticity and heterogeneity in (model) biological systems
- Advanced statistical modelling and machine learning for big data problems in (meta)genomics
Dr Chris Willcocks, Department of Computer Science
Areas of Expertise: Computer Science
Research Interests: Deep generative modelling, such as diffusion probabilistic models and normalising flows, with applications in unpaired domain translation, anomaly detection, physics, biology and chemistry.
Professor J.A. Gareth Williams, Department of Chemistry
Areas of Expertise: Synthetic Chemistry, Metal Complexes, Luminescence and Bio-imaging
Research Interests
- Luminescent sensors for bioactive ions and molecules in solution
- New sensors for magnesium ions with improved selectivity over calcium
- Development of new chelating agents based on naturally occurring siderophores
- Phosphorescent molecules for visible and NIR-light-emitting devices