IAS Fellow's Seminar - In vivo assembly of intermediate filaments: interplay between turnover and transport
Abstract: Intermediate filaments are one of the components of cytoskeletal networks; they organize via a series of assembly/disassembly and transport events. Understanding the assembly dynamics of intermediate filaments, their organization in networks and resulting mechanical properties is essential to elucidate their functions in cells. Keratin is an intermediate filament protein expressed by epithelial cells. A combination of mathematical modelling and experimental data is used to investigate the organization of the keratin network in cells and its perpetual motion from the periphery to the center of cells. What contributes to the keratin organization? What process or combination of processes does the perpetual inward motion emerge from? What process dominates this emergent phenomenon?
Fellows' seminars take place on Monday lunchtimes in the seminar room at Cosin's Hall.
Places are limited and so any academic colleagues interested in attending a seminar should contact the Institute in advance to reserve a place.
The aim of these seminars is to develop new thinking on the big issues that are of current concern/interest for the Fellows . Each Fellow is asked to present a core idea that informs their current work, or a problem that they are tackling, that could benefit from cross-disciplinary thinking. These seminars are informal and designed to encourage discussion.
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