Publication details for Prof. Graham SandfordHarsanyi, A. & Sandford, G. (2015). Fluorine gas for life science syntheses: green metrics to assess selective direct fluorination for the synthesis of 2-fluoromalonate esters. Green Chemistry 17(5): 3000-3009.
- Publication type: Journal Article
- ISSN/ISBN: 1463-9262 (print), 1463-9270 (electronic)
- DOI: 10.1039/C5GC00402K
- Further publication details on publisher web site
- Durham Research Online (DRO) - may include full text
Author(s) from Durham
Optimisation and real time reaction monitoring of the synthesis of 2-fluoromalonate esters by direct fluorination using fluorine gas is reported. An assessment of green metrics including atom economy and process mass intensity factors, demonstrates that the one-step selective direct fluorination process compares very favourably with established multistep processes for the synthesis of fluoromalonates.