Publication details for Prof. Graham SandfordBreen, J.R., Sandford, G., Patel, B. & Fray, J. (2015). Synthesis of 4,4-difluoro-1H-pyrazole derivatives. Synlett 26(01): 51-54.
- Publication type: Journal Article
- ISSN/ISBN: 0936-5214 (print), 1437-2096 (electronic)
- DOI: 10.1055/s-0034-1378915
- Keywords: Organofluorine, Fluoroheterocycle, Pyrazole, Selective fluorination, Fluoropyrazole.
- Further publication details on publisher web site
- Durham Research Online (DRO) - may include full text
Author(s) from Durham
Fluorination of 3,5-diarylpyrazole substrates by SelectfluorTM in acetonitrile gave 4,4-difluoro-1H-pyrazoles in addition to 4-fluoropyrazole derivatives. The structure of this new class of fluorinated heterocycle was established by X-ray crystallography.