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Durham University

Department of Chemistry

Publication details for Prof. Graham Sandford

Breen, J.R., Sandford, G., Patel, B. & Fray, J. (2015). Synthesis of 4,4-difluoro-1H-pyrazole derivatives. Synlett 26(01): 51-54.

Author(s) from Durham


Fluorination of 3,5-diarylpyrazole substrates by SelectfluorTM in acetonitrile gave 4,4-difluoro-1H-pyrazoles in addition to 4-fluoropyrazole derivatives. The structure of this new class of fluorinated heterocycle was established by X-ray crystallography.