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Durham University

Department of Chemistry

Publication details for Prof. Graham Sandford

Harsanyi, A., Sandford, G., Yufit, D.S. & Howard, J.A.K. (2014). Syntheses of fluoro-oxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester. Beilstein Journal of Organic Chemistry 10: 1213-1219.

Author(s) from Durham


Diethyl 2-fluoromalonate ester is utilised as a building block for the synthesis of 2-fluoro-2-arylacetic acid and fluorooxindole derivatives by a strategy involving nucleophilic aromatic substitution reactions with ortho-fluoronitrobenzene substrates followed by decarboxylation, esterification and reductive cyclisation processes.