Publication details for Prof. Graham SandfordHarsanyi, A., Sandford, G., Yufit, D.S. & Howard, J.A.K. (2014). Syntheses of fluoro-oxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester. Beilstein Journal of Organic Chemistry 10: 1213-1219.
- Publication type: Journal Article
- ISSN/ISBN: 1860-5397
- DOI: 10.3762/bjoc.10.119
- Keywords: Fluorinated building blocks, Fluoroarylacetic acid, Fluoromalonate, Fluorooxindole, Organo-fluorine, Selective fluorination.
- Further publication details on publisher web site
- Durham Research Online (DRO) - may include full text
Author(s) from Durham
Diethyl 2-fluoromalonate ester is utilised as a building block for the synthesis of 2-fluoro-2-arylacetic acid and fluorooxindole derivatives by a strategy involving nucleophilic aromatic substitution reactions with ortho-fluoronitrobenzene substrates followed by decarboxylation, esterification and reductive cyclisation processes.