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Durham University

Department of Chemistry

Publication details for Prof. Graham Sandford

Cargill, M.R., Sandford, G., Kilickiran, P. & Nelles, G. (2013). Pd-catalysed sp2-sp cross-coupling reactions involving aromatic C-F bond activation in highly fluorinated nitrobenzene systems. Tetrahedron 69(2): 512-516.

Author(s) from Durham


Direct and regioselective alkynylation of highly fluorinated nitrobenzene derivatives by palladium-catalyzed Sonogashira type processes is described, representing the first examples of metal-catalyzed sp2–sp cross-coupling reactions involving C–F bond activation.