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Durham University

Department of Chemistry

Publication details for Prof. Graham Sandford

Harsanyi, Antal, Lueckener, Anne, Pasztor, Hedvig, Yilmaz, Zahide, Tam, Lawrence, Yufit, Dmitry & Sandford, Graham (2020). a-Fluorotricarbonyl derivatives as versatile fluorinated building blocks: synthesis of fluoro-acetophenone, fluoro-ketoester and fluoro-pyran-4-one derivatives. European Journal of Organic Chemistry 2020(25): 3872-3878.

Author(s) from Durham


Fluorinated acyl‐Meldrum’s acid derivatives were synthesised by electrophilic fluorination of appropriate phenacyl Meldrum’s acid substrates using Selectfluor. Reactions with water, ethanol, Grignard and alkynyl lithium reagents gave rise to the corresponding fluoro‐acetophenone, ‐1,3‐ketoester, ‐1,3‐diketone and ‐pyran‐4‐one products respectively from the same selectively fluorinated scaffold in one‐step procedures.