Publication details for Prof. Graham SandfordHarsanyi, Antal, Lueckener, Anne, Pasztor, Hedvig, Yilmaz, Zahide, Tam, Lawrence, Yufit, Dmitry & Sandford, Graham (2020). a-Fluorotricarbonyl derivatives as versatile fluorinated building blocks: synthesis of fluoro-acetophenone, fluoro-ketoester and fluoro-pyran-4-one derivatives. European Journal of Organic Chemistry 2020(25): 3872-3878.
- Publication type: Journal Article
- ISSN/ISBN: 1434-193X (print)
- DOI: 10.1002/ejoc.202000503
- Further publication details on publisher web site
- Durham Research Online (DRO) - may include full text
Author(s) from Durham
Fluorinated acyl‐Meldrum’s acid derivatives were synthesised by electrophilic fluorination of appropriate phenacyl Meldrum’s acid substrates using Selectfluor. Reactions with water, ethanol, Grignard and alkynyl lithium reagents gave rise to the corresponding fluoro‐acetophenone, ‐1,3‐ketoester, ‐1,3‐diketone and ‐pyran‐4‐one products respectively from the same selectively fluorinated scaffold in one‐step procedures.