Publication details for Prof. Graham SandfordSato, Kazuyuki, Sandford, Graham, Konishi, Yukiko, Yanada, Niko, Toda, Chisako, Tarui, Atsushi & Omote, Masaaki (2019). Lewis acid promoted fluorine-alkoxy group exchange reactions for the synthesis of 5-alkoxy-4,4-difluoroisoxazoline systems. Organic & Biomolecular Chemistry 17(10): 2818-2823.
- Publication type: Journal Article
- ISSN/ISBN: 1477-0520 (print), 1477-0539 (electronic)
- DOI: 10.1039/C9OB00097F
- Further publication details on publisher web site
- Durham Research Online (DRO) - may include full text
Author(s) from Durham
Fluorine-alkoxy group exchange reactions of fluorinated isoxazoline derivatives promoted by Lewis acids to give various 5-alkoxylated 4,4-difluoroisoxazolines via SN1 type processes in good to excellent yields are reported. Sterically demanding phenol substrates such as 2,6-diphenylphenol gave novel aryl substituted products via electrophilic aromatic substitution.