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Durham University

Department of Chemistry

Publication details for Prof. Graham Sandford

Sato, Kazuyuki, Sandford, Graham, Konishi, Yukiko, Yanada, Niko, Toda, Chisako, Tarui, Atsushi & Omote, Masaaki (2019). Lewis acid promoted fluorine-alkoxy group exchange reactions for the synthesis of 5-alkoxy-4,4-difluoroisoxazoline systems. Organic & Biomolecular Chemistry 17(10): 2818-2823.

Author(s) from Durham


Fluorine-alkoxy group exchange reactions of fluorinated isoxazoline derivatives promoted by Lewis acids to give various 5-alkoxylated 4,4-difluoroisoxazolines via SN1 type processes in good to excellent yields are reported. Sterically demanding phenol substrates such as 2,6-diphenylphenol gave novel aryl substituted products via electrophilic aromatic substitution.