Publication details for Prof. Graham SandfordLisse, Etienne & Sandford, Graham (2018). Synthesis of β-fluoro(dicarbonyl)ethylamines from 2-fluoro-ethylacetoacetate and dimethyl-2-fluoromalonate ester by batch and semi-continuous flow three-component Mannich reactions. Journal of Fluorine Chemistry 206: 117-124.
- Publication type: Journal Article
- ISSN/ISBN: 0022-1139 (print)
- DOI: 10.1016/j.jfluchem.2017.12.012
- Further publication details on publisher web site
- Durham Research Online (DRO) - may include full text
Author(s) from Durham
Multi-component Mannich reactions between 2-fluoro-ethylacetoacetate or dimethyl-2-fluoromalonate ester, aldehyde and amine components allowing convenient synthesis of β-fluoro(dicarbonyl)ethylamine systems using both batch and continuous flow techniques are reported.