Publication details for Prof. Ritu KatakyBen Rayana, M.C., Burnett, R.W., Covington, A.K., D'Orazio, P., Fogh-Andersen, N., Jacobs, E., Kataky, R., Kulpmann, W.R., Kuwa, K., Larsson, L., Lewenstam, A., Maas, A.H.J., Mager, G., Naskalski, J.W., Okorodudu, A.O., Ritter, C. & St John, A. (2006). Recommendation for measuring and reporting chloride by ISEs in undiluted serum, plasma or blood. Clinical chemistry and laboratory medicine 44(3): 346-352.
- Publication type: Journal Article
- ISSN/ISBN: 1434-6621, 1437-4331
- DOI: 10.1515/CCLM.2006.060
- Keywords: Blood, Chloride (ionized and total), Coulometry, Ion-selective electrode, Plasma, Standardization.
- Further publication details on publisher web site
Author(s) from Durham
The proposed recommendation for measuring and reporting chloride in undiluted plasma or blood by ion-selective electrodes (ISEs) will provide results that are identical to chloride concentrations measured by coulometry for standardized normal plasma or blood samples. It is applicable to all current ISEs dedicated to chloride measurement in undiluted samples that meet the requirements. However, in samples with reduced water concentration, results by coulometry are lower than by ion-selective electrode due to volume displacement. The quantity measured by this standardized ISE procedure is called the ionized chloride concentration. It may be clinically more relevant than the chloride concentration as determined by coulometry, photometry or by ISE after dilution of the sample.