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Durham University

Department of Chemistry

Publication details for Dr Kalesh Karunakaran

Clulow, James A., Storck, Elisabeth M., Lanyon-Hogg, Thomas, Kalesh, Karunakaran A., Jones, Lyn H. & Tate, Edward W. (2017). Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chemical Communications 53(37): 5182-5185.

Author(s) from Durham

Abstract

Sulforaphane is a small molecule isothiocyanate which exhibits
anticancer potential, yet its biological targets remain poorly understood.
Here we employ a competition-based chemical proteomics strategy to
profile sulforaphane’s targets and identify over 500 targets along with
their relative affinities. These targets provide a new set of mediators
for sulforaphane’s bioactivity, and aid understanding of its complex
mode of action.