Publication details for Dr Kalesh KarunakaranClulow, James A., Storck, Elisabeth M., Lanyon-Hogg, Thomas, Kalesh, Karunakaran A., Jones, Lyn H. & Tate, Edward W. (2017). Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chemical Communications 53(37): 5182-5185.
- Publication type: Journal Article
- ISSN/ISBN: 1359-7345 (print), 1364-548X (electronic)
- DOI: 10.1039/C6CC08797C
- Further publication details on publisher web site
- Durham Research Online (DRO) - may include full text
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Author(s) from Durham
Sulforaphane is a small molecule isothiocyanate which exhibits
anticancer potential, yet its biological targets remain poorly understood.
Here we employ a competition-based chemical proteomics strategy to
profile sulforaphane’s targets and identify over 500 targets along with
their relative affinities. These targets provide a new set of mediators
for sulforaphane’s bioactivity, and aid understanding of its complex
mode of action.