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Durham University

Department of Chemistry

Publication details for Prof. Andrew Beeby

De Ornellas, S., Slattery, J.M., Edkins, R.M., Beeby, A., Baumann, C.G. & Fairlam, I.J.S. (2015). Design and synthesis of fluorescent 7-deazaadenosine nucleosides containing pi-extended diarylacetylene motifs. Organic & Biomolecular Chemistry 13(1): 68-72.

Author(s) from Durham

Abstract

C-modified 7-deazaadenosines containing a diphenylacetylene moiety have been synthesised using cross-coupling approaches. The C-modified nucleosides exhibit remarkable fluorescence properties, including high quantum yields. Solvatochromic studies show a near linear correlation between the Stokes shift and solvent polarity which is indicative of intramolecular charge transfer. DFT calculations have allowed us to correlate the experimentally observed photophysical properties with the calculated HOMO–LUMO energy gaps within a series of real and model compounds.