Publication details for Dr Margarita StaykovaStubbington, Liam, Arroyo, Marino & Staykova, Margarita (2017). Sticking and sliding of lipid bilayers on deformable substrates. Soft Matter 13(Themed collection Soft Matter Emerging Investigators 2017): 181-186.
- Publication type: Journal Article
- ISSN/ISBN: 1744-683X (print), 1744-6848 (electronic)
- DOI: 10.1039/C6SM00786D
- Further publication details on publisher web site
- Durham Research Online (DRO) - may include full text
Author(s) from Durham
We examine here the properties of lipid bilayers coupled to deformable substrates. We show that by changing the extent of the substrate hydrophilicity, we can control the membrane–substrate coupling and the response of the bilayer to strain deformation. Our results demonstrate that lipid bilayers coupled to flexible substrates can easily accommodate large strains, form stable protrusions and open reversibly pores. These properties, which differ significantly from those of free standing membranes, can extend the applications of the current lipid technologies. Moreover, such systems better capture the mechanical architecture of the cell interface and can provide insights into the capacity of cells to reshape and respond to mechanical perturbations.