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Department of Chemistry

Prof. Nigel Robinson, (Professor of Biology)

Professor in the Department of Biosciences

(email at nigel.robinson@durham.ac.uk)

THE MOLECULAR CELL BIOLOGY OF METALS

About a third of proteins, and perhaps a half of enzymes, require metals. How do the different metals locate to the correct proteins? My research group analyse the contributions of gene products associated with the (i) perception-, (ii) acquisition or export-, (iii) intracellular distribution or storage-, of essential metals. The lab is funded by BBSRC and industrial partners. Applications of Metals in Biology research are promoted by a BBSRC-funded Academia-Industry network.

ANNOUNCEMENTS

Foster, A.W., Pernil R., Patterson, C.J., Scott, A.J.P., Pålsson, L-O, Pal, R., Cummins, I., Chivers, P.T., Pohl, E. Robinson, N.J. (2017) A tight tuneable range for Ni(II)-sensing and -buffering in cells. Nature Chemical Biology, 13: 409-414. 'F1000Prime recommended'

Osman, D., Piergentili, C., Chen, J., Sayer, L.N., Usón, I., Huggins, T.G., Robinson, N.J., Pohl, E. (2016) The effectors and sensory sites of formaldehyde-responsive regulator FrmR and metal-sensing variant. Journal of Biological Chemistry 291: 19502-19516.

Rubio, M.A., Napolitano, M., Ochoa de Alda, J.A.G., Santamaría-Gómez, J., Patterson, C.J., Foster, A.W., Bru-Martínez, R., Robinson, N.J., Luque, I. (2015) Trans-oligomerization of duplicated aminoacyl-tRNA synthetases maintains genetic code fidelity under stress. Nucleic Acids Research 43: 9905-9917.

Osman, D., Piergentili, C., Chen, J., Chakrabarti, B., Foster, A.W., Lurie-Luke, E., Huggins, T.G., Robinson, N.J. (2015) Generating a metal-responsive transcriptional regulator to test what confers metal sensing in cells. Journal of Biological Chemistry 290: 19806-19822.

Foster, A.W., Osman, D., Robinson, N.J. (2014) Metal preferences and metallation. Journal of Biological Chemistry 289: 28095-28103.

Foster, A.W., Dainty, S.J., Patterson, C.J., Pohl, E., Blackburn, H., Wilson, C., Hess, C.R., Rutherford, J.C., Quaranta, L., Corran, A., Robinson, N.J. (2014) A chemical potentiator of copper-accumulation used to investigate the iron-regulons of Saccharomyces cerevisiae. Molecular Microbiology 93: 317-330.

Foster, A.W., Pernil, R., Patterson, C.J., Robinson, N.J. (2014) Metal specificity of cyanobacterial nickel-responsive repressor InrS: cells maintain zinc and copper below the detection threshold for InrS. Molecular Microbiology 92: 797-812.

Raven, E., Le Brun, N.E., McMaster, J., Reedijkd, J., Robinson, N.J. (2013) Bioinorganic chemistry. Dalton Transactions 42: 3027-3028.

Osman, D., Patterson, C.J., Bailey, K., Fisher, K., Robinson, N.J., Rigby, S.E., Cavet, J.S. (2013) The copper supply pathway to a Salmonella Cu,Zn-superoxide dismutase (SodCII) involves P(1) (B)-type ATPase copper efflux and periplasmic CueP. Molecular Microbiology 87: 466-477.

Patterson, C.J., Pernil, R., Dainty, S.J., Chakrabarti, B., Henry, C.E., Money, V.A., Foster, A.W., Robinson, N.J. (2013) Co(II)-detection does not follow Kco(II) gradient: channelling in Co(II)-sensing. Metallomics 5: 352-362.

Tottey, S., Patterson, C.J., Banci, L., Bertini, I., Felli, I.C., Pavelkova, A., Dainty, S.J., Pernil, R., Waldron, K.J., Foster, A.W., Robinson, N.J. (2012) Cyanobacterial metallochaperone inhibits deleterious side reactions of copper. Proceedings of the National Academy of Sciences 109: 95-100. 

Foster, A.W., Patterson, C.J., Pernil, R., Hess, C.R., Robinson, N.J. (2012) A cytosolic Ni(II) sensor in a cyanobacterium: nickel-detection follows nickel-affinity across four families of metal sensors. Journal of Biological Chemistry 287: 12142-12151.

Napolitano, M., Rubio, M.A., Santamaría-Gómez, J., Olmedo-Verd, E., Robinson, N.J., Luque, I. (2012) Characterization of the response to zinc-deficiency in the cyanobacterium Anabaena sp. strain PCC 7120 Journal of Bacteriology 194: 2426-2436.

Tu, W.Y., Pohl, S., Gray, J., Robinson, N.J., Harwood, C.R., Waldron, K.J. (2012) Cellular iron distribution in Bacillus anthracis. Journal of Bacteriology 194: 932-940.

Robinson, N.J. (2011) A platform for copper pumps Nature 475: 41-42.

Foster, A.W., Robinson, N.J. (2011) Promiscuity and preferences of metallothioneins: the cell rules. BMC Biology 9: 25.

Waldron, K.J., Firbank, S.J., Dainty, S.J., Pérez-Rama, M., Tottey, S., Robinson, N.J. (2010) Structure and metal loading of a soluble periplasm cuproprotein. Journal of Biological Chemistry 285: 32504-32511.

Osman, D., Waldron, K.J., Denton, H., Taylor, C.M., Grant, A.J., Mastroeni, P., Robinson, N.J., Cavet, J.S. (2010) Copper homeostasis in salmonella is atypical and copper-CueP is a major periplasmic metal complex. Journal of Biological Chemistry 285: 25259-25268.

Paynter, J.J., Andres-Enguix, I., Fowler, P.W., Tottey, S., Cheng, W., Enkvetchakul, D., Bavro, V.N., Kusakabe, Y., Sansom, M.S., Robinson, N.J., Nichols, C.G., Tucker, S.J. (2010) Functional complementation and genetic deletion studies of KirBac channels: activatory mutations highlight gating-sensitive domains. Journal of Biological Chemistry 285: 40754-40761.

Robinson, N.J., Winge, D.R. (2010) Copper metallochaperones. Annual Review of Biochemistry 79: 537-562.

Banci, L., Bertini, I., Ciofi-Baffoni, S., Poggi, L., Vanarotti, M., Tottey, S., Waldron, K.J., Robinson, N.J. (2010) NMR structural analysis of the soluble domain of ZiaA-ATPase and the basis of selective interactions with copper metallochaperone Atx1. Journal of Biological Inorganic Chemistry 15: 87-98.

Dainty, S.J., Patterson, C.J., Waldron, K.J., Robinson, N.J. (2010) Interaction between cyanobacterial copper chaperone Atx1 and zinc homeostasis. Journal of Biological Inorganic Chemistry 15: 77-85.

Waldron, K.J., Rutherford, J.C., Ford, D., Robinson, N.J. (2009) Metalloproteins and metal-sensing Nature 460: 823-830.

Waldron, K.J., Robinson, N.J. (2009) How do bacterial cells ensure that metalloproteins get the correct metal? Nature Reviews Microbiology 7: 25-35.

Tottey, S., Waldron, K.J., Firbank, S.J., Reale, B., Bessant, C., Sato, K., Cheek, T.R., Gray, J., Banfield, M.J., Dennison, C., Robinson, N.J. (2008) Protein-folding location can regulate manganese-binding versus copper- or zinc-binding. Nature, 455: 1138-1142.

Badarau, A., Firbank, S.J., Waldron, K.J., Yanagisawa, S., Robinson, N.J., Banfield, M.J., Dennison, C. (2008) FutA2 is a ferric binding protein from Synechocystis PCC 6803. Journal of Biological Chemistry 283: 12520-12527.

 Refer to Orchid record for older publications.