Dr Alan Kenwright
(email at email@example.com)
Alan Kenwright got his BSc (1980) from the University of Nottingham, before obtaining an MSc (1981) and PhD (1986) in solid-state NMR at the University of East Anglia under Professor Robin Harris and Professor Ken Packer.
He did post-doctoral research with Professor Lucian Monnerie at the Ecole Superieure de Physique at Chimie Industrielles, Paris, before taking a position (1987) in the University of Durham Industrial Research Laboratories (UDIRL) doing contract research for industry and forming part of the EPSRC solid-state NMR service.
In 1989 he joined the newly-formed Interdisciplinary Research Centre (IRC) in Polymer Science and Technology at Durham University under Professor Jim Feast as a Research Fellow. During this time he set up the IRC's solution-state NMR facility while maintaining an active interest in solid-state NMR.
Between 1995 and 2008 he was employed as the solution-state NMR manager in the Chemistry Department at Durham University and in 2008 he was promoted to Reader in recognition of his contributions to research and teaching in the department. He has published over 100 research articles and is active in a range of research areas.
Solution-state NMR is one of the most useful techniques for characterising the chemical nature of substances that can be dissolved. The nuclei of certain isotopes possess spin angular momentum ("spin") and the interaction of this spin with radio frequency radiation in the presence of a magnetic field provides a probe, which is uniquely sensitive to the precise distribution of electrons about the nucleus. Information can be obtained not only about the chemical environment of the various nuclei present, but also about their connectivity and topology.
Typical uses of solution-state NMR range from quantitative fingerprinting of complex mixtures through confirmation of product structure with identification of residual solvents and other impurities, to full structural elucidation of unknowns.
The Analytical Centre in the Chemistry Department at Durham University is extremely well equipped for solution-state NMR investigations, having six spectrometers housed in a purpose-built suite of laboratories. The six spectrometers operate at a range of magnetic field strengths corresponding to proton resonance frequencies of 200, 400 (x3), 500, 600 and 700 MHz. (Increased magnetic field strength gives greater resolution and greater sensitivity.)
My research interests centre on the application of NMR techniques to a wide range of chemical problems, with particular interest in NMR characterisation of paramagnetic lanthanide complexes and NMR studies of diffusion.
Paramagnetic Lanthanide complexes
Paramagnetic Lanthanide complexes have found widespread application in recent years both as contrast agents in Magnetic Resonance Imaging (MRI) and as luminescent probes for bio-assay. The characterisation of such complexes by NMR presents particular challenges since the chemical shift range for the protons on ligands complexed to the paramagnetic ion can be in excess of 1000 ppm (compared with the usual range for diamagnetic substances of around 10 ppm).
Pulsed field gradient spin echo NMR is generally the method of choice for diffusion measurements on liquid samples. With modern high field instruments, however, severe problems can arise when it is applied to samples with very high proton concentrations because of the presence of radiation damping. We have recently been involved in developing methods to avoid these problems, and also in developing pulse sequences to extend these measurements to three-dimensional spectra such as HMQC-DOSY.
- Kenwright, Alan M., Aguilar, Juan A., Koley Seth, Banabithi & Kuprov, Ilya (2020). Coherence transfer delay optimisation in PSYCOSY experiments. Magnetic Resonance in Chemistry 58(1): 51-55.
- Hewitt, Sarah H., Macey, Georgina, Mailhot, Romain, Elsegood, Mark R. J., Duarte, Fernanda, Kenwright, Alan M. & Butler, Stephen J. (2020). Tuning the anion binding properties of lanthanide receptors to discriminate nucleoside phosphates in a sensing array. Chemical Science 11(14): 3619-3628.
- Aguilar, Juan A., Belda, Raquel, Gaunt, Benjamin R., Kenwright, Alan M. & Kuprov, Ilya (2018). Separating the coherence transfer from chemical shift evolution in high-resolution pure shift COSY NMR. Magnetic Resonance in Chemistry 56(10): 969-975.
- Routledge, Jack D., Zhang, Xuejian, Connolly, Michael, Tropiano, Manuel, Blackburn, Octavia A., Kenwright, Alan M., Beer, Paul D., Aldridge, Simon & Faulkner, Stephen (2017). Lanthanide Complexes that Respond to Changes in Cyanide Concentration in Water. Angewandte Chemie International Edition 56(27): 7783-7786.
- Sørensen, Thomas Just, Tropiano, Manuel, Kenwright, Alan M. & Faulkner, Stephen (2017). Triheterometallic Lanthanide Complexes Prepared from Kinetically Inert Lanthanide Building Blocks. European Journal of Inorganic Chemistry 2017(15): 2165-2172.
- Aguilar, Juan A., Ball, Andrew T., Coxon, Christopher R., Kenwright, Alan M., Lancaster, Robert W., Mosely, Jackie A. & Mutton, Matthew A. (2016). Amorphism and Thermal Decomposition of Salicylsalicylic Acid - A Cautionary Tale. Journal of Pharmaceutical Sciences 105(10): 3073-3078.
- Blackburn, O. A., Edkins, R. M., Faulkner, S., Kenwright, A. M., Parker, D., Rogers, N. J. & Shuvaev S. (2016). Electromagnetic susceptibility anisotropy and its importance for paramagnetic NMR and optical spectroscopy in lanthanide coordination chemistry. Dalton Transactions 45(16): 6782-6800.
- Blackburn, O. A., Tropiano, M., Natrajan, L. S., Kenwright, A. M. & Faulkner, S. (2016). Luminescence of a binuclear europium complex bearing a 4-nitrophenolate chromophore: a different way of seeing pH dependence. Chemical Communications 52(36): 6111-6114.
- Swinburne, A. N., Langford Paden, M.H., Chan, T. L., Randall, S., Ortu, F., Kenwright, A. M. & Natrajan, L. S. (2016). Optical Properties of Heavily Fluorinated Lanthanide Tris β-Diketonate Phosphine Oxide Adducts. Inorganics 4(4): 27.
- Blackburn, Octavia A., Routledge, Jack D., Jennings, Laura B., Rees, Nicholas H., Kenwright, Alan M., Beer, Paul D. & Faulkner, Stephen (2016). Substituent effects on fluoride binding by lanthanide complexes of DOTA-tetraamides. Dalton Transactions 45(7): 3070-3077.
- Blackburn, O.A., Kenwright, A.M., Beer, P.D. & Faulkner, S. (2015). Axial fluoride binding by lanthanide DTMA complexes alters the local crystal field, resulting in dramatic spectroscopic changes. Dalton Transactions 44(45): 19509-19517.
- Funk, A.M., Harvey, P., Finney, K.-L.N.A., Fox, M.A., Kenwright, A.M., Rogers, N.J., Senanayake, P.K. & Parker, D. (2015). Challenging lanthanide relaxation theory: erbium and thulium complexes that show NMR relaxation rates faster than dysprosium and terbium analogues. Physical Chemistry Chemical Physics 17(25): 16507-16511.
- Tropiano, M., Kenwright, A. M. & Faulkner, S. (2015). Lanthanide Complexes of Azidophenacyl-DO3A as New Synthons for Click Chemistry and the Synthesis of Heterometallic Lanthanide Arrays. Chemistry - A European Journal 21(15): 5697-5699.
- Blackburn, O.A., Chilton, N.F., Keller, K., Tait, C.E., Myers, W.K., McInnes, E.J., Kenwright, A.M., Beer, P.D., Timmel, C.R. & Faulkner, S. (2015). Spectroscopic and Crystal Field Consequences of Fluoride Binding by [Yb⋅DTMA](3+) in Aqueous Solution. Angewandte Chemie International Edition 54(37): 10783-10786.
- Aguilar, J.A., Kiraly, P., Adams, R.W., Bonneau, M., Grayson, E.J., Nilsson, M., Kenwright, A.M. & Morris, G.A. (2015). Ultra-high dispersion NMR reveals new levels of detail. RSC Advances 5(65): 52902-52906.
- Aguilar, Juan A., Morris, Gareth A. & Kenwright Alan M. (2014). "Pure shift" 1H NMR, a robust method for revealing heteronuclear couplings in complex spectra. RSC Advances 4(16): 8278-8282.
- Funk, AM, Fries, PH, Harvey, P, Kenwright, AM & Parker, D (2013). Experimental Measurement and Theoretical Assessment of Fast Lanthanide Electronic Relaxation in Solution with Four Series of Isostructural Complexes. The Journal of Physical Chemistry A 117(5): 905-917.
- Allain, Clemence, Beer, Paul D., Faulkner, Stephen, Jones, Michael W., Kenwright, Alan M., Kilah, Nathan L., Knighton, Richard C., Sørensen, Thomas Just & Tropiano, Manuel (2013). Lanthanide appended rotaxanes respond to changing chloride concentration. Chemical Science 4(1): 489-493.
- Sørensen, TJ, Tropiano, M, Blackburn, OA, Tilney, JA, Kenwright, AM & Faulkner, S (2013). Preparation and study of an f,f,f′,f′′ covalently linked tetranuclear hetero-trimetallic complex – a europium, terbium, dysprosium triad. Chemical Communications 49(8): 783-785.
- Habgood, M., Lancaster, R. W., Gateshki, M. & Kenwright, A. M. (2013). The Amorphous Form of Salicylsalicylic Acid: Experimental Characterization and Computational Predictability. Crystal Growth & Design 13(4): 1771-1779.
- Tropiano, Manuel Blackburn, Octavia A. Tilney, James A. Hill, Leila R. Placidi, Matteo P. Aarons, Rebecca J. Sykes, Daniel, Jones, Michael W. Kenwright, Alan M. , Snaith, John S. Sørensen, Thomas Just & Faulkner, Stephen (2013). Using Remote Substituents to Control Solution Structure and Anion Binding in Lanthanide Complexes. Chemistry - A European Journal 19(49): 16566-16571.
- Walton, JW, Carr, R, Evans, NH, Funk, AM, Kenwright, AM, Parker, D, Yufit, DS, Botta, M, De Pinto, S & Wong, K (2012). Isostructural Series of Nine-Coordinate Chiral Lanthanide Complexes Based on Triazacyclononane. Inorganic Chemistry 51(15): 8042-8056.
- Kenwright, Alan M. & Sellars, Jonathan D. (2012). Preparation and complete 1 H and 13C assignment of some pentacyclo [5.4.0.02,6.03,10.05,9]undecane-8,11-dione (PCUD) derivatives. Magnetic Resonance in Chemistry 50(12): 803-808.
- Kunamaneni, S., Buzza, D.M.A., Read, D.J., Parker, D., Kenwright, A.M., Feast, W.J. & Larsen, A.L. (2006). Entanglement transition of randomly branched polymers in the hyperbranched class. Macromolecules 39(19): 6720-6736.
- Feast, W.J., Gimeno, M. & Kenwright, A.M. (2006). Synthesis and radical polymerization of 1,1-difluoro-2-vinylcyclopropane a reexamination and structural reassignment. Macromolecules 39(12): 4076-4080.
- Feast, W.J., Gimeno, M. & Kenwright, A.M. (2006). Synthesis and radical ring opening behaviour of 1,1-difluoro-2-heptyl-2-vinylcyclopropane and some of its isomers. Journal of flourine chemistry 127(12): 1533-1539.