Prof. Ritu Kataky
(email at email@example.com)
Materials for sensing, delivery of actives and drugs
We use liposomes, gels and nanomaterials for in-vivo and in-vitro sensing and delivery. The aim is to develop materials that are biocompatible and ’soft’ for replacing solid state devices. The picture on the left shows a PEDOT/CNT modified biocompatible hydrogel which is electrochemical and mechano sensitive.
This work additionally extends to collaborative work with Procter and Gamble for delivery of actives.
Electrochemical measurement of electron and ion transport at liquid-liquid interfaces
Electrochemistry at the liquid‑liquid interface or the interface between two immiscible electrolyte solutions (ITIES) is a simple model of the biological membrane. It provides a means to study the transfer of a wide range of compounds. These electrochemical processes are especially interesting as they can provide information about the non-redox-active species, whole cells, bioactive molecules and ions. We have used the liquid liquid interfac for studying chiral interctions between drugs and proteins, lipid‑bioactive molecule interactions amongst others.
Current collaborative work with Procter and Gamble extends to studying detergency at a liquid-liquid interface.
Interactions of lipid membranes and cell mimics with bioactive molecules
Electron and ion transfer properties of supported and black lipid membranes modified with membrane associated molecules are studied using electrochemistry, impedance spectroscopy and Scanning Electrochemical Microscopy.
Developing sensors and biosensors for environmental, clinical and pharmaceutical monitoring.
We have developed sensors electrochemical sensors for a wide range of applications in novel formats includingchiral sensors, multi‑analyte sensing platforms microelectrode arrays, chemically responsive micro grippers, sensors for formaldehyde monitoring amongst others.
- Ntola, C.N.M. & Kataky, R. (2017). ‘Soft’ electroactive particles and their interaction with lipid membranes. Electrochemistry Communications 77: 65-70.
- Carter, Z.A. & Kataky, R. (2017). A G-quadruplex aptamer based impedimetric sensor for free lysine and arginine. Sensors and Actuators B: Chemical 243: 904-909.
- Chowdhury, Mehrin & Kataky, Ritu (2016). Emulsification at the liquid-liquid interfaces: effects of potential, electrolytes and surfactants. ChemPhysChem 17(1): 105-111.
- Kataky, R., Hadden, J.H.L., Coleman, K.S., Ntola, C.N.M., Chowdhury, M., Duckworth, A.R., Dobson, B.P., Campos, R., Pyner, S. & Shenton F. (2015). Graphene oxide nanocapsules within silanized hydrogels suitable for electrochemical pseudocapacitors. Chemical Communications 51(51): 10345-10348.
- Daunton, R., Wood, D., Gallant, A.J. & Kataky, R. (2014). A microgripper sensor device capable of detecting ion efflux from whole cells. RSC Advances 4(92): 50536-50541.
- Sulaiman, Y. & Kataky, R. (2012). Chiral acid selectivity displayed by PEDOT electropolymerised in presence of chiral molecules. Analyst 137(10): 2386-2393.
- P.Lopes & R.Kataky (2012). Chiral interactions of the drug propranolol and α1 acid glycoprotein at a micro Liquid-liquid Interface. Analytical Chemistry 84(5): 2299–2304.
- Rui Campos & Ritu Kataky (2012). Electron transport in supported and tethered lipid bilayers modified with bioelectroactive molecules. The Journal of Physical Chemistry B 116(13): 3909-3917.
- Sulaiman, Y., Knight, M. R. & Kataky, R. (2012). Non-invasive monitoring of temperature stress in Arabidopsis thaliana roots, using ion amperometry. Analytical Methods 4(6): 1656-1661.
- Dellavalle, A., Maroli, G., Covarello, D., Azzoni, E., Innocenzi, A., Perani, L., Antonini, S., Sambasivan, R., Brunelli, S., Tajbakhsh, S. & Cossu, G. (2011). Pericytes resident in postnatal skeletal muscle differentiate into muscle fibres and generate satellite cells. Nature Communications 2(1): 499.
- Dias-Gunasekara, S., van Lith, M., Kataky, R., Williams, G. & Benham, A.M. (2006). Expression, interactions and dynamics of the oxidoreductase Ero1Lbeta. FASEB journal 20(4): A500.
- Filby, M.H., Humphries, T.D., Turner, D.R., Kataky, R., Kruusma, J. & Steed, J.W. (2006). Modular assembly of a preorganised, ditopic receptor for dicarboxylates. Chemical communications 2006(2): 156-158.
- Dias-Gunasekara, S., van Lith, M., Williams, J.A.G., Kataky, R. & Benham, A.M. (2006). Mutations in the FAD binding domain cause stress-induced misoxidation of the endoplasmic reticulum oxidoreductase Ero1b. Journal of Biological Chemistry 281(35): 25018-25025.
- Ben Rayana, M.C., Burnett, R.W., Covington, A.K., D'Orazio, P., Fogh-Andersen, N., Jacobs, E., Kataky, R., Kulpmann, W.R., Kuwa, K., Larsson, L., Lewenstam, A., Maas, A.H.J., Mager, G., Naskalski, J.W., Okorodudu, A.O., Ritter, C. & St John, A. (2006). Recommendation for measuring and reporting chloride by ISEs in undiluted serum, plasma or blood. Clinical chemistry and laboratory medicine 44(3): 346-352.
- Szarma, R.J., Batsanov, A.S., Kataky, R. & Baruah, J.B. (2006). Structural investigations on quinone methides for understanding their properties in confined media. Journal of inclusion phenomena and macrocyclic chemistry 55(1-2): 1-9.