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Department of Chemistry

Dr Lars-Olof Pålsson

Assistant Professor in the Department of Chemistry
Telephone: +44 (0) 191 33 42135

(email at

Research Interests

Chemical physics and biophysics. I am interested in the application of optical spectroscopy and microscopy for investigations of biological systems and organic materials for display applications, molecular electronics and sensing of the biological environment. The work is interdisciplinary and relies on collaborations with colleagues active in synthetic chemistry and cell biology.

Modulation of the excited state by the di-electric medium

We are interested in how the medium affects the excited state decay and this is monitored using mainly time-resolved emission techniques. The aim of this work is to explore the sensing ability in organic chromophores and organo metallic complexes. 

Luminescence imaging and time-resolved emission microscopy

We are using luminescence imaging to study bio-active materials using emissive probes. The excited state decay of organic fluorescence probes and organo metallic complexes is monitored using time-resolved luminescence microscopy.

Time-gated detection is illustrated above. In the experiment the short lived fluorescence from the matrix has decayed before the gate is turned on and the photoluminescence from the metal centered emission is exclusively monitored. In combination we are also using conventional photon counting techniques to study the organic fluorescence. We are using microscope detection enabling single cells to be studied. We can study the excited state decay of many different types of emissive probes over a very wide dynamic range over 100 orders of magnitude.

Polarised luminescence spectroscopy for molecular recognition and sensing.

We are pursuing circularity polarised luminescence spectroscopy as a tool to study biological systems. This methodology can be used to investigate stereo specific inter-molecular interactions between functionalised optical probes and chiral biological macromolecules such as proteins.



  • Anil Suri, Rui Campos, Darius G. Rackus, Nicholas J.S. Spiller, Christine Richardson, Lars-Olof Pålsson and Ritu Kataky (2011). Liposome-doped hydrogel for implantable tissue. Soft Matter. 7, 7071-7077.
  • Lisa Murphy,Aileen Congreve,Lars-Olof Pålssonand J. A. Gareth Williams (2010). The time domain in co-stained cell imaging: time-resolved emission imaging microscopy using a protonatable luminescent iridium complex. Chem. Comm. 43, 8743 - 8745.
  • Lars-Olof Pålsson, Benjamin S. Nehls, Frank Galbrecht, Benjamin A. Coombs, Fernando B. Dias, Tony Farrell, Ullrich Scherf, and Andrew P. Monkman (2010). Excited state dynamics and optical characteristics of oligophenyl based cruci forms in solution and solid state. J. of Phys. Chem. B, 114(40), 12765 - 12776.
  • Lars-Olof Pålsson, Changsheng Wang, Andrei S. Batsanov, Simon M. King, Andrew Beeby, Andrew P. Monkman and Martin R. Bryce (2009). Intramolecular charge transfer in molecular wires comprised Oligoyne-Bridged Oxadiazol-Triphenylamine Dipoles: Synthesis, x-Ray Crystal Structure, Solution Electrochemistry and opto-electronic properties. Chem. Eur. J. 16, 1470-1479.
  • Evan G. Moore, Géza Szigethy, Jide Xu, Lars-Olof Pålsson, Andrew Beeby and Kenneth N. Raymond (2008). 3,2-HOPO Complexes of Near Infra-Red (NIR) Emitting Lanthanides: Sensitization of Ho(III) and Pr(III) in Aqueous Solution. Angewandte Chemie Interdit. 47, 9500-9503.
  • Lars-Olof Pålsson, Robert Pal, Benjamin S. Murray, David Parker and Andrew Beeby (2007) Two-photon absorption and photoluminescence of europium based emissive probes for bioactive systems. J. of Dalton Trans. 2007, 5726-5734.

Selected Publications

Chapter in book

Journal Article

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