Dr David R.W. Hodgson
(email at email@example.com)
David Hodgson read Natural Sciences in Cambridge, and pursued a Ph.D. with Professor Anthony J. Kirby focusing on biological catalysis and physical organic chemistry. David moved to a PDRA position in Toronto with Professor J. B. Jones to explore subtilisin bioconjugates for directed proteolysis of protein targets. Supported by a Royal Society-Fulbright post-doctoral fellowship, David moved to Buffalo NY, to work on in vitro selection of ribozymes with Professor Hiroaki Suga. David then took up a lectureship in Durham in 2003, focusing on using physical organic chemistry, particularly towards biological problems. He works on nucleosides, nucleotides and nucleic acids, and enzymes that process these species. He also has strong interests in nucleic acid and protein bioconjugates, carbohydrate polymers and commercially relevant enzyme systems. He was Director of Undergraduate Studies in Chemistry 2009-2014, and was promoted to senior lecturer in 2013.
The DRWH group uses physical organic chemistry to approach biological and synthetic chemistry problems. Key themes are the use of kinetics and the understanding and exploitation of physico-chemical properties to enable more effective synthetic and bioconjugation procedures.
We have developed convenient phosphorylation methods, and apply our results with protein kinase, polymerase and cyclase enzymes. We study reactivity in water, and apply this towards effective synthetic and bioconjugation procedures. We also use polysaccharide-based biopolymers as feedstocks for new materials. We work within the Sustainable Chemistry and Catalysis, and Biological Chemistry research groups, linking to collaborators in Durham through the Biophysical Sciences Institute. We also collaborate with several groups outside the UK.
Nucleosides, Nucleotides and Nucleic Acids
We use aqueous and non-aqueous approaches to prepare nucleosides, nucleotides and phosphate ester mimics. We use our chemistry to provide substrates and mechanistic understanding in enzyme systems.
Reactivity in Water and Bioconjugations
We use kinetic understanding and speciation control alongside our synthetic techniques to provide effective conjugations and synthetic methods.
Biopolymers are abundant, renewable resources that offer frameworks for elaboration into new materials. In collaboration, we have applied our approaches towards both chitinous and cellulosic materials.
- 24: Delley, R.J., O'Donoghue, A.C. & Hodgson, D.R.W. (2012). Hydrolysis studies of phosphodichloridate and thiophosphodichloridate ions. The Journal of Organic Chemistry 77(13): 5829–5831.
- 26: Skipsey, M., Hack, G., Hooper, T. A., Shankey, M. C., Conway, L. P., Schröder, M. & Hodgson, D. R. W. (2013). 5’-Deoxy-5’-hydrazinylguanosine as an initiator of T7 RNA polymerase-catalyzed transcriptions for the preparation of labeling-ready RNAs. Nucleosides, Nucleotides, and Nucleic Acids 32(12): 670-681.
- 28: Conway, L. P., Delley, R. J., Neville, J., Freeman, G. R., Maple, H. J., Chan, V., Hall, A. J. & Hodgson, D. R. W. (2014). The Aqueous N-Phosphorylation and N-Thiophosphorylation of Aminonucleosides. RSC Advances 2014(73): 38663-38671.
- 30: Korhonen, Heidi J., Bolt, Hannah L., Vicente-Gines, Leyre, Perks, Daniel C. & Hodgson, David R. W. (2015). PPN pyrophosphate: A New Reagent for the Preparation of Nucleoside Triphosphates. Phosphorus, Sulfur, and Silicon and the Related Elements 190(5-6): 758-762.
- 31: Carvalho, A., O’Donoghue, A. C., Hodgson, D. R. W. & Kamerlin, S. C. L. (2015). Understanding Thio-Effects in Simple Phosphoryl Systems: Role of Solvent Effects and Nucleophile Charge. Organic and Biomolecular Chemistry 13(19): 5391-5398.
- 33: Joubert, Fanny, Musa, Osama, Hodgson, David R. W. & Cameron, Neil R. (2015). Graft copolymers of hydroxyethyl cellulose by a ‘grafting to’ method: 15N labelling as a powerful characterisation tool in ‘click’ polymer chemistry. Polymer Chemistry 6(9): 1567-1575.
- 34: Korhonen, H. J., Bolt, H. L. & Hodgson, D. R. W. (2015). A procedure for the preparation and isolation of nucleoside-5’-diphosphates. Beilstein Journal of Organic Chemistry 11: 469-472.
- 35: Townsend, P.D., Rodgers, T.L., Glover, L.C., Korhonen, H.J., Richards, S.A., Colwell, L.J., Pohl, E., Wilson, M.R., Hodgson, D.R.W., McLeish, T.C.B. & Cann, M.J. (2015). The role of protein-ligand contacts in allosteric regulation of the Escherichia coli Catabolite Activator Protein. Journal of Biological Chemistry 290(36): 22225-22235.
- 36: Dano, Meisa, Elmeranta, Marjukka, Hodgson, David R.W., Jaakkola, Juho, Korhonen, Heidi & Mikkola, Satu (2015). Metal–ion promoted cleavage of nucleoside diphosphosugars: A model for reactions of phosphodiester bonds in carbohydrates. Journal of Biological Inorganic Chemistry 20(8): 1299-1306.
- 38: Eguaogie, Olga, Cooke, Leonie A., Martin, Patricia M. L., Ravalico, Francesco, Conway, Louis P., Hodgson, David R. W., Law, Christopher J. & Vyle, Joseph S. (2016). Synthesis of novel pyrophosphorothiolate-linked dinucleoside cap analogues in a ball mill. Organic and Biomolecular Chemistry 14(4): 1201-1205.
- 39: Conway, L. P., Mikkola, S., O’Donoghue, A. C. & Hodgson, D. R. W. (2016). The Synthesis, Conformation and Hydrolytic Stability of an N,S-bridging Thiophosphoramidate Analogue of Thymidylyl-3ʹ,5ʹ-Thymidine. Organic & Biomolecular Chemistry 14(30): 7361-7367.
- 40: Eguaogie, Olga, Conlon, Patrick F., Ravalico, Francesco, Sweet, Jamie S. T., Elder, Thomas B., Conway, Louis P., Lennon, Marc E., Hodgson, David R. W. & Vyle, Joseph S. (2017). Nucleophilic displacement reactions of 5′-derivatised nucleosides in a vibration ball mill. Beilstein Journal of Organic Chemistry 13: 87-92.
- 41: Hodgson, David R.W. (2017). Physicochemical Aspects of Aqueous and Nonaqueous Approaches to the Preparation of Nucleosides, Nucleotides and Phosphate Ester Mimics. In Advances in Physical Organic Chemistry. Williams, N.H. & Williams, I.H. Elsevier. 50.