Bioactive Chemistry and Synthesis
The Bioactive Chemistry and Synthesis grouping aims to address a range of exciting challenges at the interface between chemistry and biology.
Members within the Bioactive Chemistry and Synthesis grouping have scientific expertise in a diverse range of areas including; Synthetic Organic Chemistry, Chemical-Biology, Biochemistry, Bio-inorganic Chemistry, and Structural and Analytical Chemistry. Research in the area of Bioactive Chemistry and Synthesis is extremely well supported by state-of-the-art facilities located within the Department. Members of the research grouping are engaged in exciting interdisciplinary projects which are funded through a variety of funding agencies (e.g. EPSRC, BBSRC, MRC, Wellcome Trust, Leverhulme Trust, European Commission, the Royal Society, British Society for Antimicrobial Chemotherapy and the British Heart Foundation) and via collaboration with industry (e.g. AstraZeneca, GSK, Unilever and Syngenta).
Research Group Leader: TBC
Interdisciplinary Research Embedded in the Chemistry Department
Several researchers from both the School of Biological and Biomedical Sciences (SBBS) and the School of Medicine, Pharmacy and Health (SMPH) are located in embedded biology laboratories within the Department of Chemistry. This provides a unique research environment which supports exciting interdisciplinary collaborations at the Chemistry-Biology interface.The following SBBS and SMPH academic staff located in Chemistry and they are affiliate members of the Bioactive Chemistry and Synthesis research grouping : Dr Tim Blower, Dr Martin Cann, Dr Peter Chivers, Dr Paul Denny, Professor Nigel Robinson, Dr Gary Sharples and Dr Paul Yeo.
Members of the Bioactive Chemistry and Synthesis research grouping also work closely with academic staff working within the Biomolecular Interactions research group -
Patel, Jignesh J., Laars, Marju, Gan, Wei, Board, Johnathan, Kitching, Matthew O. & Snieckus, Victor (2018). Directed Remote Lateral Metalation: Highly Substituted 2-Naphthols and BINOLs by In Situ Generation of a Directing Group. Angewandte Chemie - International Edition 57(30): 9425-9429.
Gimenez, D., Aguilar, J.A., Bromley, E.H.C. & Cobb, S.L. (2018). Stabilising Peptoid Helices Using Non-Chiral Fluoro-Alkyl Monomers. Angewandte Chemie International Edition 57(33): 10549-10553.
Linthwaite, V.L., Janus, J.M., Brown, A.P., Wong-Pascua, D., O’Donoghue, A.C., Porter, A., Treumann, A., Hodgson, D.R.W. & Cann, M.J. (2018). The identification of carbon dioxide mediated protein post-translational modifications. Nature Communications 9: 3092.
Sturala, Jiri, Etherington, Marc K., Bismillah, Aisha N, Higginbotham, Heather F., Trewby, William J., Aguilar, Juan A., Bromley, Elizabeth H. C., Avestro, Alyssa-Jennifer, Monkman, Andrew P. & McGonigal, Paul R. (2017). Excited-State Aromatic Interactions in the Aggregation-Induced Emission of Molecular Rotors. Journal of the American Chemical Society 139(49): 17882-17889.
Bozhkov, Peter, Kunz, Hans-Henning, Hu, Jinping, Neuhaus, H. Ekkehard, Steel, Patrick G. & Smertenko, Andrei (2017). Impact of salt stress, cell death, and autophagy on peroxisomes: quantitative and morphological analyses using small Fluorescent probe N-BODIPY. Scientific Reports 7: 39069.
De Bo, Guillaume, Gall, Malcolm A. Y., Kitching, Matthew O., Kuschel, Sonja, Leigh, David A., Tetlow, Daniel J. & Ward, John W. (2017). Sequence-Specific β-Peptide Synthesis by a Rotaxane-Based Molecular Machine. Journal of the American Chemical Society 139(31): 10875-10879.
Yeung, Chi-Tung, Yim, King-Him, Wong, Ho-Yin, Pal, Robert, Lo, Wai-Sum, Yan, Siu-Cheong, Yee-Man Wong, Melody, Yufit, Dmitry, Smiles, Danil E., McCormick, Laura J., Teat, Simon J., Shuh, David K., Wong, Wing-Tak & Law, Ga-Lai (2017). Chiral transcription in self-assembled tetrahedral Eu4L6 chiral cages displaying sizable circularly polarized luminescence. Nature Communications 8(1): 1128.
Routledge, Jack D., Zhang, Xuejian, Connolly, Michael, Tropiano, Manuel, Blackburn, Octavia A., Kenwright, Alan M., Beer, Paul D., Aldridge, Simon & Faulkner, Stephen (2017). Lanthanide Complexes that Respond to Changes in Cyanide Concentration in Water. Angewandte Chemie International Edition 56(27): 7783-7786.
García-López, Víctor, Chen, Fang, Nilewski, Lizanne G., Duret, Guillaume, Aliyan, Amir, Kolomeisky, Anatoly B., Robinson, Jacob T., Wang, Gufeng, Pal, Robert & Tour, James M. (2017). Molecular machines open cell membranes. Nature 548(7669): 567-572.
Grant, Jacob A., Lu, Zhou,, Tucker, David E., Hockin, Bryony M., Yufit, Dmitry S., Fox, Mark A., Kataky, Ritu, Chechik, Victor & O'Donoghue, AnnMarie C. (2017). New Blatter-type radicals from a bench-stable carbene. Nature Communications 8: 15088.
Mina, John, Thye, Julie, Alqaisi, Amjed, Bird, Louise, Dods, Robert, Groftehauge, Morten, Mosely, Jackie, Pratt, Steven, Shams-Eldin, Hosam, Schwarz, Ralph, Pohl, Ehmke & Denny, Paul W. (2017). Functional and phylogenetic evidence of a bacterial origin for the first enzyme in sphingolipid biosynthesis in a phylum of eukaryotic protozoan parasites. Journal of Biological Chemistry 292(29): 12208-12219.
Foster, A.W., Pernil, R., Patterson, C.J., Scott, A.J.P., Pålsson, L.-O., Pal, R., Cummins, I., Chivers, P.T., Pohl, E. & Robinson, N.J. (2017). A tight tunable range for Ni(II) sensing and buffering in cells. Nature Chemical Biology 13(4): 409-414.