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Department of Chemistry

Seminars

Seminars are usually held on Wednesday at 14:00 in CG60, but you should check the seminar details for exceptions.

2018 RSC Dalton Meeting

Presented by Department of Chemistry, Durham University

2 July 2018 09:30 in CG85

The 2018 RSC Dalton Meeting will be held at Durham University. Confirmed speakers include:

Prof. Sven Schneider (Goettingen, Germany)
Prof. Matt Rosseinsky FRS (Liverpool, UK)

Full programme to follow.

Contact p.w.dyer@durham.ac.uk or karen.johnston@durham.ac.uk for more information

Mini-Symposium on boron-catalysed amidation: from theory to practice

Presented by Department of Chemistry, Durham University

6 July 2018 10:00 in Musgrave Room

10.00 am Professor Henry Rzepa, Imperial College, London

Title: Computational catalysis: mechanistic reality checks.

Abstract: Computational chemistry can provide valuable reality checks for unravelling the mechanistic basis for catalytic processes. The process will be illustrated for reaction pathways of boron-based amidation catalysts and reagents, the use of calculated 11B NMR chemical shifts for helping to identify putative reaction intermediates and the publication of FAIR data archives as part of the scholarly publication processes.

10.30 am Dr Tom Sheppard, University College, London

Title: Borate esters as highly effective catalysts for direct amidation

Abstract: Simple borate esters such as B(OMe)3 and B(OCH2CF3)3 were found to very effective catalysts for mediating the direct amidation between carboxylic acids and amines. The reactions have an extremely wide substrate scope, and can be carried out very efficiently on large scale to produce multigram quantities of amide. The presentation will cover the development of this reaction, along with insights into the reaction mechanisms.

11.15 Coffee

11.45 Professor Kazuaki Ishihara, Nagoya University, Japan

Title: Rational design of high performance catalysts using boron Lewis acids

Abstract: We have studied on rational design of high performance catalysts based on acid–base combination chemistry. In this lecture, two topics will be focused. One is “Boronic Acid Catalysts for Dehydrative Condensation between Carboxylic Acids and Amines.”1 The other is “Boron Lewis Acid-assisted Chiral Brønsted Acid Catalysts for Enantioselective Cycloadditions.”2

References
1. (a) Wang, K.; Yanhui, Lu, Ishihara, K. to be submitted. (b) Yanhui, L.; Wang, K.; Ishihara, K. Asian J. Org. Chem. 2017, 6, 1111. (c) Ishihara, K.; Yanhui, L. Chem. Sci. 2017, 7, 1276.
2. (a) Hatano, M.; Sakamoto, T.; Ishihara, K. to be submitted. (b) Sakamoto, T.; Mochizuki, T.; Goto, Y.; Hatano, M.; Ishihara, K. Chem. Asian J. 2018, 13, in press. (c) Hatano, M.; Hayashi, K.; Sakamoto, T.; Makino, Y.; Ishihara, K. Synlett 2016, 27, 1061. (d) Hatano, M.; Ishihara, H.; Goto, Y.; Ishihara, K. Synlett 2016, 27, 564. (e) Hatano, M.; Goto, Y.; Izumiseki, A.; Akakura, M.; Ishihara, K. J. Am. Chem. Soc. 2015, 137, 13472. (f) Hatano, M.; Mizuno, T.; Izumiseki, A.; Usami, R.; Asai, T.; Akakura, M.; Ishihara, K. Angew. Chem. Int. Ed. 2011, 50, 12189.

12.45 Buffet lunch

Contact andy.whiting@durham.ac.uk for more information

TBA

Presented by Prof. Rafal Klajn, Weizmann Institute of Science (Israel) Winner of the 2018 Cram Lehn Pedersen Prize in Supramolecular Chemistry

17 July 2018 14:00 in TBC

Contact jon.steed@durham.ac.uk for more information