Seminars are usually held on Wednesday at 14:00 in CG60, but you should check the seminar details for exceptions.
2018 RSC Dalton Meeting
2 July 2018 09:30 in CG85
The 2018 RSC Dalton Meeting will be held at Durham University. Confirmed speakers include:
Prof. Sven Schneider (Goettingen, Germany)
Prof. Matt Rosseinsky FRS (Liverpool, UK)
Full programme to follow.
Mini-Symposium on boron-catalysed amidation: from theory to practice
6 July 2018 10:00 in Musgrave Room
10.00 am Professor Henry Rzepa, Imperial College, London
Title: Computational catalysis: mechanistic reality checks.
Abstract: Computational chemistry can provide valuable reality checks for unravelling the mechanistic basis for catalytic processes. The process will be illustrated for reaction pathways of boron-based amidation catalysts and reagents, the use of calculated 11B NMR chemical shifts for helping to identify putative reaction intermediates and the publication of FAIR data archives as part of the scholarly publication processes.
10.30 am Dr Tom Sheppard, University College, London
Title: Borate esters as highly effective catalysts for direct amidation
Abstract: Simple borate esters such as B(OMe)3 and B(OCH2CF3)3 were found to very effective catalysts for mediating the direct amidation between carboxylic acids and amines. The reactions have an extremely wide substrate scope, and can be carried out very efficiently on large scale to produce multigram quantities of amide. The presentation will cover the development of this reaction, along with insights into the reaction mechanisms.
11.45 Professor Kazuaki Ishihara, Nagoya University, Japan
Title: Rational design of high performance catalysts using boron Lewis acids
Abstract: We have studied on rational design of high performance catalysts based on acid–base combination chemistry. In this lecture, two topics will be focused. One is “Boronic Acid Catalysts for Dehydrative Condensation between Carboxylic Acids and Amines.”1 The other is “Boron Lewis Acid-assisted Chiral Brønsted Acid Catalysts for Enantioselective Cycloadditions.”2
1. (a) Wang, K.; Yanhui, Lu, Ishihara, K. to be submitted. (b) Yanhui, L.; Wang, K.; Ishihara, K. Asian J. Org. Chem. 2017, 6, 1111. (c) Ishihara, K.; Yanhui, L. Chem. Sci. 2017, 7, 1276.
2. (a) Hatano, M.; Sakamoto, T.; Ishihara, K. to be submitted. (b) Sakamoto, T.; Mochizuki, T.; Goto, Y.; Hatano, M.; Ishihara, K. Chem. Asian J. 2018, 13, in press. (c) Hatano, M.; Hayashi, K.; Sakamoto, T.; Makino, Y.; Ishihara, K. Synlett 2016, 27, 1061. (d) Hatano, M.; Ishihara, H.; Goto, Y.; Ishihara, K. Synlett 2016, 27, 564. (e) Hatano, M.; Goto, Y.; Izumiseki, A.; Akakura, M.; Ishihara, K. J. Am. Chem. Soc. 2015, 137, 13472. (f) Hatano, M.; Mizuno, T.; Izumiseki, A.; Usami, R.; Asai, T.; Akakura, M.; Ishihara, K. Angew. Chem. Int. Ed. 2011, 50, 12189.
12.45 Buffet lunch
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17 July 2018 14:00 in TBC
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