Tuesday Lunchtime Research Meetings 2017-18
The meeting will usually start at 12 noon with a buffet lunch, with talks starting at 12:30. More details will be provided by email just before the event.
31 October 2017
“Lytic Reactions Of Lipid Membranes”
by John Sanderson (https://www.dur.ac.uk/chemistry/staff/profile/?id=198)
“On the move: molecular rearrangement and macroscopic motion”
by Matt Kitching (https://www.dur.ac.uk/chemistry/staff/profile/?id=15807)
(Matt and John’s talks are aimed to coincide with the biophysical theme of the annual Howard Prize Lecture that takes place in the New Ogden Physics building later in the day: https://www.dur.ac.uk/bsi/events/?eventno=36558)
7 November 2017
“Integrative Modelling of Macromolecular Assemblies”
by Matteo Degiacomi (https://degiacomi.org)
“Transient absorption: a general tool for probing excited states”
by Allie Tyson (JRRV group www.verlet.net)
14 November 2017
“Light Activated Nanomachines for Targeted Therapeutics”
by Robert Pal (https://www.dur.ac.uk/chemistry/staff/profile/?id=6011)
“Fluorescent retinoids for cell biology and beyond”
by David Chisholm (AW group https://www.dur.ac.uk/chemistry/staff/profile/?id=204)
28 November 2017
“The synthesis, characterisation and properties of triplet harvesting emissive organic molecules”
by Jonathan Ward (MRB group https://www.dur.ac.uk/chemistry/staff/profile/?id=172)
“Finding needles in haystacks: sea cucumbers, reaction monitoring; and more”
by Juan Aguilar (https://www.dur.ac.uk/chemistry/staff/profile/?id=11141)
THURSDAY 14 December 2017
lunch from 1 pm with talk starting at 1:15 pm
“Manipulating controlled radical polymerization to control architecture, functionality and morphology”
by Athina Anastasaki (University of California, Santa Barbara https://scholar.google.co.uk/citations?user=wFpF2_kAAAAJ&hl=en)
In this talk the development of new controlled radical polymerization strategies will be presented, including atom transfer radical polymerization (ATRP), reversible addition-fragmentation chain transfer (RAFT) polymerization and emulsion polymerization. These synthetic strategies give access to advanced materials consisting of hydrophilic, hydrophobic, semi-fluorinated and functional segments. Although traditional polymerization strategies require various parameters to be optimized to achieve a high degree of control over molecular weight and dispersity, this work demonstrates that one set of universal conditions can be achieved. These universal conditions result in efficacious polymerization of different classes of monomers, including acrylates, methacrylates and styrene. The facile nature of these conditions, combined with readily available reagents, will greatly expand the availability of tailored polymeric materials to all researchers. Ultimately, the synthesis of complex, sequence-controlled multiblock copolymers will reveal advanced materials that exhibit unique characteristics and morphologies.
23 January 2018
running 10 am - 5 pm
"Drug Discovery and Delivery II"
- Drug Discovery and Delivery II schedule (last modified: 18 January 2018)
30 January 2018
"Polarisation and order in biological networks: equilibrium and (some) dynamics"
by Kristian Müller-Nedebock, Dept of Physics, Stellenbosch University South Africa (www)
The mechanical and transport properties of a cell depend on the precise nature of networks which make up the cytoskeleton. The distribution and orientation of filaments within the finite region of the cell also vary with position within the cell and can be imaged. Molecular dynamics simulations show that confinement affects the orientation and distribution of filaments within the cell [Azari, A. & Müller-Nedebock, K. K. EPL (2015)]. A monomer ensemble technique allows us to understand branching and cross-linking in finite networks consisting of stiff filaments. We also briefly discuss active cross-linkers in networks, restricting our view to the one-dimensional contractile ring, and two-dimensional motility assays [Mebwe Pachong, S. & Müller-Nedebock, K. K. EPJE (2017)].
"Fluid transport through fluid tubes"
by Buddhapriya Chakrapati, Department of Physics, University of Sheffield (www)
Motivated by experiments I will talk about some recent ideas to understand fluid flow through nano-fluidic channels.
20 February 2018
"Challenging Catalytic C–H Bond Activation"
by Uwe Schneider, University of Edinburgh (www)
13 March 2018
"Sex, drugs and rock ‘n’ roll: the secret life of Euglena gracilis"
by Ellis O'Niel University of Oxford (www)
FRIDAY 4 May 2018
Synthetic chemistry mini-symposium
Musgrave Room, 11:30 – 15:10
11:30-12:10 Dr Adam Calow, Bower Group, University of Bristol, "Medium ring lactams via N-directed carbonylative C-C bond activation"
12:10-12:50 Jay Wright, PGS Group, Durham University, "Regioselective Borylation of Heterocycles"
Organoboron compounds are of great importance to organic, medicinal and materials chemistry, representing key intermediates for the introduction of a wide variety of functional groups. This is best exemplified by the Suzuki-Miyaura cross-coupling. In recent years, the direct C-H borylation of arenes has become an attractive method for the synthesis of aryl boronate esters. However, this transformation is more challenging for heterocycles bearing an azinyl nitrogen atom, where the presence of the nitrogen lone pair can inhibit the reaction. This is particularly evident at the proximal C-H bond, where C-H activation often does not occur. Whilst many heterocycles have been investigated, aminopyrazoles remain underexplored. This nucleus features in an array of bioactive molecules, such as herbicides, anti-cancer, and anti-parastic drugs. In this presentation, we will describe a simple method for the selective C-H functionalization at both azinyl and remote C-H positions of 3- and 5- aminopyrazoles.
Lunch break sponsored by Buchi
13:30-14:10 Dr Na (Anna) Wu, Guangxi Normal University in Guilin, China (currently visiting Oxford)
"Transition-metal catalysed enynes domino (cascade) reactions"
14:10-15:10 ProfessorJean-François Soulé, University of Rennes, France, "Transition Metal-Catalyzed C–H Bond Functionalization: Application to the Synthesis of Life and Material Molecules"
5. a) M. Brahim, H. Ben Ammar, V. Dorcet, J.-F. Soulé, H. Doucet, Org. Lett. 2017, 19, 2584; b) C.-S. Wang, T. Roisnel, P. H. Dixneuf, J.-F. Soulé, Org. Lett. 2017, 19, 6720; c) C.-S. Wang, P. H. Dixneuf, J.-F. Soulé, ChemCatChem 2017,9, 3117
15:10 tea and discussions
8 May 2018
"From metal-free cross-couplings to radical cyclization cascades: new methods for synthesis"
Prof. David Procter, University of Manchester (www)
MONDAY 14 May 2018
"Process Understanding: A Tool in Chemical Process Development"
Dr Ian Ashworth, AstraZeneca, Macclesfield
"Photochemistry on a Computer"
Dr Basile Churchod, Durham (www)
22 May 2018
"Molecular tug-of-war: promoting reactions with force"
Dr Guiliaume De Bo, University of Manchester (www)
"Gel-Based Approaches to Novel Crystal Forms"
Prof. Jonathan Steed, Durham (www)
FRIDAY 6th July
Mini-Symposium on boron-catalysed amidation: from theory to practice
10.00-10.30 Professor Henry Rzepa, Imperial College, London
"Computational catalysis: mechanistic reality checks"
Computational chemistry can provide valuable reality checks for unravelling the mechanistic basis for catalytic processes. The process will be illustrated for reaction pathways of boron-based amidation catalysts and reagents, the use of calculated 11B NMR chemical shifts for helping to identify putative reaction intermediates and the publication of FAIR data archives as part of the scholarly publication processes.
10.30-11.15 Dr Tom Sheppard, University College, London
"Borate esters as highly effective catalysts for direct amidation"
Simple borate esters such as B(OMe)3and B(OCH2CF3)3were found to very effective catalysts for mediating the direct amidation between carboxylic acids and amines. The reactions have an extremely wide substrate scope, and can be carried out very efficiently on large scale to produce multigram quantities of amide. The presentation will cover the development of this reaction, along with insights into the reaction mechanisms.