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Wolfson Research Institute for Health and Wellbeing



Djoko, Karrera Y., Achard, Maud E. S., Phan, Minh-Duy, Lo, Alvin W., Miraula, Manfredi, Prombhul, Sasiprapa, Hancock, Steven J., Peters, Kate M., Sidjabat, Hanna, Harris, Patrick N., Mitić, Nataša, Walsh, Timothy R., Anderson, Gregory J., Shafer, William M., Paterson, David L., Schenk, Gerhard, McEwan, Alastair G. & Schembri, Mark A. (2018). Copper ions and coordination complexes as novel carbapenem adjuvants. Antimicrobial Agents and Chemotherapy62(2): e02280-17.

Mulla, R.S., Beecroft, M.S., Yufit, D.S., Pal, R. Aguilar, J.A., Pitarch-Jarque, J., García-España, E., Lurie-Luke, E., Sharples, G.J. and Williams, J.A.G. (2018) On the antibacterial activity of azacarboxylate ligands: lowered metal ion affinities for some bis-amide derivatives of EDTA do not necessarily mean reduced activity. Chem. Eur. J. in press

Norcliffe JL, Mina JG, Alvarez E, Cantizani J, de Dios-Anton F, Colmenarejo G, Valle SG, Marco M, Fiandor JM, Martin JJ, Steel PG, Denny PW. Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform. Sci Rep. 2018 Mar 2;8(1):3938. doi: 10.1038/s41598-018-22063-9.


Bolt, H.L., Eggimann, G.A., Jahoda, C.A.B., Zuckermann, R.N., Sharples, G.J. and Cobb, S.L. (2017) Exploring the links between peptoid antibacterial activity and toxicity. Med. Chem. Commun. 8: 886-896

Djoko, Karrera Y., Phan, Minh-Duy, Peters, Kate M., Walker, Mark J., Schembri, Mark A. & McEwan, Alastair G. (2017). Interplay between tolerance mechanisms to copper and acid stress in Escherichia coli. Proceedings of the National Academy of Sciences 114(26): 6818-6823.

A. Harsanyi, A. Conte, L. Pichon, A. Rabion, S. Grenier and G. Sandford, Org. Proc. Res. Dev., 2017, 21, 273 - 276. One-step continuous flow synthesis of WHO Essential Medicine Flucytosine using fluorine. Organic process research & development., 21 (2). pp. 273-276. DOI:10.1021/acs.oprd.6b00420.

L. Jiang, R. Lan, T. Huang, C.-F. Chan, H. Li, S. Lear, J. Zong, W.-Y. Wong, M. M.-Lan Lee, B. D. Chan, W.-L. Chan, W.-S. Lo, N.-K. Mak, M. L. Lung, G. S. Taylor, Z.-X. Bian, W. C. S. Tai, G.-L. Law, W.-T. Wong, S.L. Cobb,* and K.-L. Wong,* “EBNA1-targeted probe for the imaging and growth inhibition of tumours associated with the Epstein–Barr virus”, Nat. Biomed. Eng., 2017, 0042 [Highlighted in Nature Biomedical Engineering, 2017, 0059 and in Cell Chemical Biology, 2017, 647-648

Luo, J.L., Váradi, L., Hibbs, D.E., Perry, J.D., Anderson, R.J., Orenga, S. & Groundwater, P.W. (2017) Methods for the detection and identification of pathogenic bacteria: Past, present, and future. Chemical Society Reviews 46, 4818-4832.

Luoa Y., Bolt HL., Eggimann GA., McAuley DF., McMullan R., Curran T., Cobb SL*, Lundy FT* "Peptoid Efficacy against Polymicrobial Biofilms Determined by Using Propidium Monoazide-Modified Quantitative PCR" ChemBioChem, 2017, 18, 111– 118

Mina JG, Thye JK, Alqaisi AQI, Bird LE, Dods RH, Grøftehauge MK, Mosely JA, Pratt S, Shams-Eldin H, Schwarz RT, Pohl E, Denny PW. Functional and phylogenetic evidence of a bacterial origin for the first enzyme in sphingolipid biosynthesis in a phylum of eukaryotic protozoan parasites. J Biol Chem. 2017 Jul 21;292(29):12208-12219. doi: 10.1074/jbc.M117.792374. Epub 2017 Jun 2.

Perry, J.D. (2017) A decade of development in chromogenic culture media for clinical microbiology, in an era of molecular diagnostics. Clinical Microbiology Reviews 30, 449-479.

Natalie J. Tatum, John W. Liebeschuetz, Jason C. Cole, Rosangela Frita, Adrien Herledan, Alain R. Baulard, Nicolas Willand and Ehmke Pohl. New active leads for tuberculosis booster drugs by structure-based drug discovery. Org. Biomol. Chem., 2017,15, 10245-10255


Aldred, K.J., Blower, T.R., Kerns, R.J., Berger, J.M. & Osheroff, N. (2016). Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase. Proceedings of the National Academy of Sciences of the United States of America 113(7): E839-E846.

Blower, T.R., Williamson, B.H., Kerns, R.J. & Berger, J.M. (2016). Crystal structure and stability of gyrase–fluoroquinolone cleaved complexes from Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America 113(7): 1706-1713.


Groftehauge, M. K., Hajizadeh, N. R., Swann, M. J. & Pohl, E. Protein–ligand interactions investigated by thermal shift assays (TSA) and dual polarization interferometry (DPI)(2015). Acta Cryst. D71, 36-44.

Stockdale AJ, Phillips RO, Beloukas A, Appiah LT, Chadwick D, et al. Liver Fibrosis by Transient Elastography and Virologic Outcomes After Introduction of Tenofovir in Lamivudine-Experienced Adults With HIV and Hepatitis B Virus Coinfection in Ghana. Clin Infect Dis. 2015 Sep 15;61(6):883-91.