Staff and Governance
To contact the IMEMS administrative office please use the following details:
For the Administrator (maternity cover)
T: 0191 334 6574
For the Administrative Assistant
T: 0191 334 42974
Associate Director (World Heritage): Professor Robin Coningham - view profile
Associate Director: Professor Barbara Ravelhofer - view profile
The day-to-day running of IMEMS is the responsibility of the Core Executive Committee, comprising the Director and Associate Directors and the Administrator.
Publication detailsMaehle AH (2005). The Quantification and Differentiation of the Drug Receptor Theory, c. 1910-1960. Annals of Science 62(4): 479-500.
- Publication type: Journal Article
- ISSN/ISBN: 0003-3790, 1464-505X
- DOI: 10.1080/00033790412331312666
- Keywords: receptor theory, pharmacology, receptors, drugs
- Further publication details on publisher web site
- Durham Research Online (DRO) - may include full text
Author(s) from Durham
While historians have dealt with the origins of the concept of drug receptors in the work of Paul Ehrlich (1854-1915) and John N. Langley (1852-1925) as well as with some of its applications in modern pharmaceutical research, the history of the receptor theory as such has been neglected. Discussing major developments and conceptual changes in receptor theory between about 1910 and 1960 (including relevant contributions by A. V. Hill, A. J. Clark, J. H. Gaddum, E. J. Ariëns and others), this paper attempts to fill this gap in historiography. It provides a case study of the unfolding of research under a new paradigm, but it considers also contemporary criticism and scepticism. By the early 1960s, quantitative investigations of drug action and interpretations of the experimental findings in terms of the receptor concept had become constitutive of the emerging field of ‘molecular pharmacology’. Even then, however, receptors were still hypothetical entities.
The article is also accessible online through the library's subscription of Annals of Science.
Full Executive Committee
Our Full Executive Committee is made up of the Core Executive Committee, listed above, plus a number of executive members including:
International Advisory Board
We are extremely fortunate to have be able to call on the help and guidance of colleagues from around the world who help to shape and guide our direction, strategy and international reach. Our current Advisory Board members are: