Staff and Governance
The day-to-day running of IMEMS is the responsibility of the Core Executive Committee, comprising the Director and Associate Directors and the Administrator.
Publication details for Prof. Andrew BeebyBryden, Francesca, Maruani, Antoine, Rodrigues, João M. M., Cheng, Miffy H. Y., Savoie, Huguette, Beeby, Andrew, Chudasama, Vijay & Boyle, Ross W. (2018). Assembly of High-Potency Photosensitizer–Antibody Conjugates through Application of Dendron Multiplier Technology. Bioconjugate Chemistry 29(1): 176-181.
- Publication type: Journal Article
- ISSN/ISBN: 1043-1802 (print), 1520-4812 (electronic)
- DOI: 10.1021/acs.bioconjchem.7b00678
- Further publication details on publisher web site
- Durham Research Online (DRO) - may include full text
Author(s) from Durham
Exploitation of photosensitizers as payloads for antibody-based anticancer therapeutics offers a novel alternative to the small pool of commonly utilized cytotoxins. However, existing bioconjugation methodologies are incompatible with the requirement of increased antibody loading without compromising antibody function, stability, or homogeneity. Herein, we describe the first application of dendritic multiplier groups to allow the loading of more than 4 porphyrins to a full IgG antibody in a site-specific and highly homogeneous manner. Photophysical evaluation of UV–visible absorbance and singlet oxygen quantum yields highlighted porphyrin–dendron 14 as the best candidate for bioconjugation; with subsequent bioconjugation producing a HER2-targeted therapeutic with average loading ratios of 15.4:1. In vitro evaluation of conjugate 18 demonstrated a nanomolar photocytotoxic effect in a target cell line, which overexpresses HER2, with no observed photocytotoxicity at the same concentration in a control cell line which expresses native HER2 levels, or in the absence of irradiation with visible light.
Full Executive Committee
Our Full Executive Committee is made up of the Core Executive Committee, listed above, plus a number of executive members including:
International Advisory Board
We are extremely fortunate to have be able to call on the help and guidance of colleagues from around the world who help to shape and guide our direction, strategy and international reach. Our current Advisory Board members are: