Staff and Postgraduate Students

Dr Chris Ottley

Contact Dr Chris Ottley (email at c.j.ottley@durham.ac.uk)

Biography

BSc. (Hons) The Polytechnic Wolverhampton. 1986
PhD Essex University, 1991
1991-1992 Post doctoral researcher Imperial College, London.
1992-1995 Post doctoral researcher Lancaster University
1995-present Senior Research Officer Department of Earth Sciences University of Durham.

Career Research Highlights

Ottley has a wide ranging background in environmental analytical chemistry . In the last 15 years this has concentrated on the application of ICP-MS technologies supporting the research objectives of the Department of Earth Sciences. He has continually been developing methodologies for the low level determination of REE and other trace elements at low concentrations in geological materials, including PGE analyses in silicate rocks, low level Pt analyses in anti-cancer drug therapy (with Newcastle University Cancer Research Group, Cancer Biomarkers and Prevention Group at Leicester University) and the analysis of Cd and Te in solar cell components. He is both a member of the Royal Society of Chemistry and a Chartered Chemist.

Selected Publications

Books: sections

• Ottley, C. J, Pearson, D. G & Irvine, G.J (2003). A routine method for the dissolution of geological samples for the analysis of REE and trace elements via ICP-MS. In Plasma Source Mass Spectrometry: Applications and Emerging Technologies. Holland, J. G. & Tanner, S. D. Cambridge: Royal Society of Chemistry. 221-230.

Edited works: conference proceedings

• Ottley C.J, Davison W & Edmunds W.M (1994). Chemical reduction of nitrate in groundwaters. Environmental Contamination 6th International Conference, Delphi Greece, CEP Consultants Ltd.
• Harrison R.M & Ottley C.J (1991). Estimation of heavy metal inputs to the seas. Heavy Metals in the Environment, Edinburgh, CEP Consultants Ltd.
• Jickells T.D, Yaaqub R.R, Kane M.M, Rendell A.R, Davies T, Harrison R.M, Ottley C.J, Chester R & Bradshaw G (1991). Atmospheric inputs to the North Sea: A progress report. The Proceedings of EUROTRAC symposium, SPB Academic Publishing.

Edited works: contributions

• Chester R, Bradshaw G.F, Ottley C.J, Harrison R.M, Merrett J.L, Preston M.R, Rendell A.R, Kane M.M & Jickells T.D (1993). The atmospheric distribution of trace metals, trace organics and nitrogen species over the North Sea. In Understanding the North Sea system. H. Charnock et al. (Eds) London: The Royal Society and Chapman and Hall. 165-178.

Journal papers: academic

• Uysal, İbrahim E., Ersoy, Yalçın, Karslı, Orhan, Dilek, Yildirim, Sadıklar, M. Burhan Ottley, Chris J. Tiepolo, Massimo & Meisel, Thomas (2012). Coexistence of abyssal and ultra-depleted SSZ type mantle peridotites in a Neo-Tethyan Ophiolite in SW Turkey: Constraints from mineral composition, whole-rock geochemistry (major–trace–REE–PGE), and Re–Os isotope systematic. Lithos 132-133: 50–69.
• Jarvis, IWH Meczes, EL Thomas, HD Edmondson, RJ Veal, GJ, Boddy, AV, Ottley, CJ, Pearson, DG & Tilby, MJ (2012). Therapy-induced carboplatin-DNA adduct levels in human ovarian tumours in relation to assessment of adduct measurement in mouse tissues. BIOCHEMICAL PHARMACOLOGY 83(1): 69-77.
• Plummer, R., Wilson, R. H., Calvert, H., Boddy, A. V., Griffin, M., Sludden, J., Tilby, M. J., Eatock, M., Pearson, D. G., Ottley, C. J., Matsumura, Y., Kataoka, K. & Nishiya, T. (2011). A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours. British Journal of Cancer 104(4): 593-598.
• Howells, Lynne M., Sale, Stewart, Sriramareddy, Sathya Neelature, Irving, Glen R.B., Jones, Donald J.L., Ottley, Christopher J., Pearson, D. Graham, Mann, Christopher D., Manson, Margaret M., Berry, David P., Gescher, Andreas, Steward, William P. & Brown, Karen. (2011). Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo. International Journal of Cancer 129(2): 476-486.
• Dokuz, A, Uysal, I, Kaliwoda, M, Karsli, O, Ottley, CJ & Kandemir, R (2011). Early abyssal- and late SSZ-type vestiges of the Rheic oceanic mantle in the Variscan basement of the Sakarya Zone, NE Turkey: Implications for the sense of subduction and opening of the Paleotethys. Lithos 127(1-2): 176-191.
• Nannizzi, Sara, Veal, Gareth J., Giovannetti, Elisa, Mey, Valentina, Ricciardi, Simona, Ottley Christopher J., Del Tacca, Mario & Danesi, Romano. (2010). Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines. Cancer Chemotherapy and Pharmacology 66(3): 547-558.
• Wittig N., Webb M., Pearson D.G., Dale C.W., Ottley C.J., Hutchison M., Jensen S.M. & Luguet A. (2010). Formation of the North Atlantic Craton: Timing and mechanisms constrained from Re-Os isotope and PGE data of peridotite xenoliths from SW Greenland. Chemical Geology 276(3-4): 166-187.
• Malarkey, J., Pearson, D.G. Kjarsgaard, B. Davidson, J.P. Nowell, G.M. Ottley, C,J. & Stammer, J. (2010). From source to crust: Tracing magmatic evolution in a kimberlite and a melilitite using microsample geochemistry. Earth and Planetary Science Letters 299(1-2): 80-90.
• Klein-BenDavid, Ofra, Pearson, D. Graham, Nowell, Geoff M., Ottley, Chris, McNeill, John C.R & Cartigny, Pierre. (2010). Mixed fluid sources involved in diamond growth constrained by Sr-Nd-Pb-C-N isotopes and trace elements. EARTH AND PLANETARY SCIENCE LETTERS 289: 123-133.
• Caran, Semsettin, Coban, Hakan, Flower, Martin F. J., Ottley, C.J. & Yilmaz, Kamil. (2010). Podiform chromitites and mantle peridotites of the Antalya ophiolite, Isparta Angle (SW Turkey): Implications for partial melting and melt-rock interaction in oceanic and subduction-related settings. LITHOS 114(3-4): 307-326.
• Harlou, R. Pearson, D.G. Nowell, G.M. Ottley, C.J. & Davidson, J.P. (2009). Combined Sr isotope and trace element analysis of melt inclusions at sub-ng levels using micro milling, TIMS and ICPMS. Chem. Geol 260: 254-268.
• Roberts, D.L., Williams, K.J., Cowen, R.L., Barathova, M., Eustace, A.J. Brittain-Dissont, S., Tilby, M.J., Pearson, D.G., Ottley, C.J., Stratford, I.J. & Dive, C. (2009). Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells. British Journal of Cancer 101(8): 1290-1297.
• McNeill, J., Pearson, D. G., Klein-BenDavid, O., Nowell, G.M., Ottley, C.J. & Chinn, I. (2009). Quantitative analysis of trace element concentrations in some gem-quality diamonds. JOURNAL OF PHYSICS-CONDENSED MATTER 21.
• Harrison, Luke R. E., Ottley, Christopher J., Pearson, D. Graham, Roche, Celine, Wedge, Stephen R., Dolan, M. Eileen, Newell, David R. & Tilby, Michael J. (2009). The kinase inhibitor O(6)-cyclohexylmethylguanine (NU2058) potentiates the cytotoxicity of cisplatin by mechanisms that are independent of its effect upon CDK2. BIOCHEMICAL PHARMACOLOGY 77: 1586-1592.
• Bozkurt, Erdin, Winchester, John A., Yigitbas, Erdinc & Ottley, Christopher J. (2008). Bozkurt Erdin; Winchester John A.; Yigitbas Erdinc and Ottley Christopher J. Proterozoic ophiolites and mafic-ultramafic complexes marginal to the Istanbul Block: An exotic terrane of Avalonian affinity in NW Turkey. TECTONOPHYSICS 461: 240-251.
• Sutherland, R.A., Pearson, D.G. & Ottley, C.J. (2008). Grain size partitioning of platinum-group elements in road-deposited sediments: Implications for anthropogenic flux estimates from autocatalysts. Environmental Pollution 151(3): 503-515.
• N. Wittig, D.G. Pearson, M. Webb, C.J. Ottley, G.J. Irvine, M. Kopylova, S.M. Jensen & G.M. Nowell (2008). Origin of cratonic lithospheric mantle roots: A geochemical study of peridotites from the North Atlantic Craton, West Greenland. Earth and Planetary Science Letters 274(1-2): 24-33.
• Font L, Davidson JP, Pearson DG, Nowell GM, Jerram DA & Ottley CJ (2008). Sr and Pb isotope micro-analysis of plagioclase crystals from Skye Lavas: an insight into open-system processes in a flood basalt Province. Journal of Petrology 49(8): 1449-1471.
• Krause-Heuer, Anwen M., Wheate, Nial J., Tilby, Michael J., Pearson, Graham D., Ottley, Christopher J. & Aldrich-Wright, Janice R. (2008). Substituted beta-cyclodextrin and calix[4]arene as encapsulatory vehicles for platinum(II)-based DNA intercalators. INORGANIC CHEMISTRY 47: 6880-6888.
• Yigitbas, Erdinc, Winchester, John A. & Ottley, Christopher J. (2008). Yigitbas Erdinc; Winchester John A.; Ottley Christopher J. (2008). The geochemistry and setting of the Demirci paragneisses of the Sunnice Massif, NW Turkey. TURKISH JOURNAL OF EARTH SCIENCES 17: 421-431.
• Toothill J., Williams C.A., Macdonald R., Turner S.P., Rogers N.W., Hawkesworth C.J., Jerram D.A., Ottley C.J. & Tindle A.G. (2007). A Complex petrogenesis for an arc magmatic suite, St Kitts, Lesser Antilles. Journal of Petrology 48(1): 3-42.
• Thompson, R.N., Riches, A.J.V., Antoshechkina, P.M., Pearson, D.G., Nowell, G.M., Ottley, C.J., Dickin, A.P., Hards, V.L., Nguno, A.-K. & Niku-Paavola, V. (2007). Origin of CFB Magmatism: Multi-tiered Intracrustal Picrite–Rhyolite Magmatic Plumbing at Spitzkoppe, Western Namibia, during Early Cretaceous Etendeka Magmatism. Journal of Petrology 48(6): 1119-1154.
• Sutherland R.A., Pearson D.G. & Ottley C.J. (2007). Platinum-group elements (Ir, Pd, Pt and Rh) in road deposited sediments in two urban watersheds, Hawaii. Applied Geochemistry 22(7): 1485-1501.
• Banks C.J, Smith M., Winchester J.A., Horstwood M.S.A., Noble S.R. & Ottley C.J. (2007). Provenance of intra-Rodian basin-fills: The Lower Dalradian Supergroup, Scotland. Precambrian Research 153(1-2): 46-64.
• Font, L., Nowell, G.M., Pearson, D.G., Ottley, C.J. & Willis, S.G. (2007). Sr istope analysis of bird feathers by TIMS: a tool to trace bird migration paths and breeding sites. Journal of Analytical Atomic Spectrometry 22: 513-522.
• Bozkurt, E., Winchester, J.A., Mittwede, S.K. & Ottley, C.J. (2006). Geochemistry and tectonic implications of leucogranites and tourmalines of the southern Menderes Massif, Southwest Turkey. Geodinamica Acta 19(5): 363-390.
• Charlier, B.L.A., Ginibre, C., Morgan, D., Nowell, G.M., Pearson, D.G., Davidson, J.P. & Ottley, C.J. (2006). Methods for the microsampling and high precision analysis of strontium and rubidium isotopes at the single crystal scale for petrological and geochronological applications. Chemical Geology 232(3-4): 114-133.
• Nowell, G.M, Pearson, D.G, Ottley, C.J & Tilby, M.J (2005). Accurate determination of Pt concentrations at ultra-low levels (<<20pg) in clinical DNA samples with high Hf/Pt ratios using the thermo finnigan neptune plasma ionisation multi-collector mass spectrometer (PIMMS). Plasma Source Mass Spectrometry, Applications and Emerging Technologies 245-258.
• Pearson, D.G., Nowell, G.M. & Ottley, C.J. (2005). Dating mantle melting using the Lu-Hf isotope system. Geochemica et Cosmochimica Acta 69(10): A287-A287.
• Bellis, D.J, Nowell, G.M, Ottley, C.J, Pearson, D.G & Davison, W (2005). Solution and laser ablation analysis of sulphur isotopes with the Neptune high resolution multi-collector ICP-MS (MC-ICP-MS): Application to diffusive gradients in thin films. Plasma Source Mass Spectrometry, Current Trends and Future Developments 268-283.
• Thompson, R.N, Ottley, C.J, Smith, P.M, Pearson, D.G, Dickin A.P, Morrison, M.A, Leat, P.T & Gibson, S.A (2005). Source of the quaternary alkalic basalts, picrites and basanites of the Potrillo Volcanic Field, New Mexico, USA: lithosphere or convecting mantle?. Journal of Petrology 46(8): 1603-1643.
• Meczes, E.L., Azim-Araghi, A., Ottley, C.J., Pearson, D.G. & Tilby, M.J. (2005). Specific adducts recognised by a monoclonal antibody against cisplatin-modified DNA. Biomedical Pharmacology 70(12): 1717-1725.
• Griffiths, G.J, Koh, M.Y, Brunton, V, Cawthorne, C, Reeves, N.A, Greaves, M, Tilby, M.J, Pearson, D.G, Ottley, C.J, Workman, P, Frame, M & Dive, C (2004). Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-x(L) and increases oxaliplatin and Fas-induced apoptosis. Journal of Biological Chemistry 279(44): 46113-46121.
• Emziane, M, Ottley, C.J., Durose, K. & Halliday, D.P. (2004). Impurity analysis of CdCl2 used for thermal activation of CdTe-based solar cells. Journal of Physics D: Applied Physics 37(21): 2962-2965.
• Azim-Araghi,, C.J. Ottley, D.G. Pearson & M.J. Tilby (2003). Combination of ICP-MS and ion exchange chromatography permits analyses of specific cis-platin DNA modifications formed in cancer cells. Plasma Source Mass Spectrometry. Spec. Pub. Royal Society of Chemistry 66- 73.
• John, T., Ottley, C.J., Pearson, D.G., Nowell, G.M, Calvert, H & Tilby, M.J. (2003). Determination by ICP-MS, of background and BBR 3464 induced levels of platinum bound to DNA isolated from blood cells: A comparison of the sensitivity of the Perkin Elmer Sciex Elan 6000 and the ThermoFinnigan Neptune Instruments. Plasma Source Mass Spectrometry. Spec. Pub. Royal Society of Chemistry 82-90.
• Nowell, G.M, Pearson, D.G, Ottley, C. J, Schweiters, J & Dowall D (2003). Long-term performance characteristics of a plasma ionisation multi-collector mass spectrometer (PIMMS): the ThermoFinnigan Neptune. Plasma Source Mass Spectrometry. Spec. Pub. Royal Society of Chemistry 307-320.
• John, T, Ottley, C.J, Pearson, D.G, Nowell, G.M, Calvert, H & Tilby, M (2003). Sensitive determination of BBR 3464 and cisplatin DNA adduct levels in clinical samples using ICP-MS and PIMMS. Br. J. Cancer 88.
• Rutter, G.P, Pearson, D.G, Philip, G, Day, J.M.D & Ottley, C.J (2003). The use of ICP-MS in provenancing igneous stone artefacts: examples from the southern Levant. Plasma Source Mass Spectrometry. Spec. Pub. Royal Society of Chemistry 209-218.
• Durose, K, Boyle, D, Abken, A., Ottley, C.J., Nollet P, Degrave S, Burgelman M, Wendt R, Beier J & Bonnet D (2002). Key aspects of CdTe/CdS solar cells. physica status solidi (b) 229(2): 1055-1064.
• Azim-Araghi, A, Ottley, C.J, Pearson, D.G & Tilby, M.J (2002). Structures of atypical PLATINUM-DNA adducts in certain resistant lung cancer lines. Br. J. Cancer 86.
• Azim-Araghi, A, Ottley, C.J, Pearson, D.G & Tilby, M.J (2001). Mechanisms underlying differences in immunoreactivity of cisplatin DNA adducts formed in certain cancer cells. Br. J. Cancer 85.
• S.J. Woodland, C.J. Ottley, D.G. Pearson & R.E. Swarbrick (2001). Microwave digestion of oils for platinum group and rare earth elements by ICP-MS. In: J.G. Holland & S.D. Tanner (eds) Plasma Source Mass Spectrometry: the new Millennium, Spec. Pub. Royal Society of Chemistry 17-24.
• A. Azim-Araghi, C.J. Ottley, D.G. Pearson & M.J. Tilby (2001). Sensitive detection of platinum-bound DNA using ICP-MS and comparison to graphite furnace atomic absorption (GFAAS). IIn: J.G. Holland & S.D. Tanner (eds) Plasma Source Mass Spectrometry: the new Millennium, Spec. Pub. Royal Society of Chemistry 412-418.
• Pearson, D.G & Ottley, C.J (2001). Which way for Os ? A comparison of plasma-source versus negative thermal ionisation mass spectrometry for Os isotope measurement. In: J.G. Holland & S.D. Tanner (eds) Plasma Source Mass Spectrometry: the new Millennium, Spec. Pub. Royal Society of C 279-287.
• Azim-Araghi A, Wright K.A, Ottley C.J, Pearson D.G, Twentyman P.R & Tilby M.J (2000). Formation of atypical cisplatin DNA adducts in certain cancer cells. Br. J. Cancer 83: 65.
• Allen A.G, Baxter P.J & Ottley C.J (2000). Gas and particle emissions from Soufriere Hills Volcano, Montserrat, West Indies: characterization and health hazard assessment. B VOLCANOL 62(1): 8-19.
• Griselin, M, Pearson, D. G, Ottley, C. J & Davies, G. R (1999). A low-blank, low detection limit method for REE analysis of geological samples by isotope dilution ICP-MS. In: Holland, J. G. and Tanner, S. D., 1999, Plasma Source Mass Spectrometry - New Developments and Applications. Roy. S no 234: 246-252.
• Pearson, D. G, Ottley, C. J & Woodland, S. J (1999). Precise measurement of Osmium by direct injection nebulisation ICP-MS. In: Holland, J. G. and Tanner S. D., 1999, Plasma Source Mass Spectrometry - New Developments and Applications. Roy. So 234: 277-285.
• Zhang H, Davison W & Ottley C (1999). Remobilisation of major ions in freshly deposited lacustrine sediment at overturn. AQUAT SCI 61(4): 354-361.
• Ottley C.J, Davison W & Edmunds W.M (1997). Chemical catalysis of nitrate reduction by iron(II). Geochim. Cosmochim. Acta 61(9): 1819-1828.
• Harrison R.M, Zlatev Z & Ottley C.J (1994). A comparison of the predictions of an Eulerian atmospheric transport-chemistry model with experimental measurements over the North Sea. Atmospheric Environment 28A: 497-516.
• Asman W.A.H, Harrison R.M & Ottley C.J (1994). Estimation of the net air-sea flux of ammonia over the Southern Bight of the North Sea. Atmospheric Environment 28: 3647-3654.
• Ottley C.J & Harrison R.M (1993). The atmospheric dry deposition flux of metallic species to the North Sea. Atmospheric Environment 27A: 685-695.
• Rendell A.R, Ottley C.J, Jickells T.D & Harrison R.M (1993). Wet and dry nitrogen deposition flux estimates to the North Sea. Tellus 45B: 53-63.
• Ottley C.J & Harrison R.M (1992). The spatial distribution and particle size of some inorganic nitrogen, sulphur and chlorine species over the North Sea. Atmospheric Environment 26A: 1689-1699.
• Ottley C.J & Harrison R.M (1991). The atmospheric input flux of trace metals to the North Sea: A review and recommendations for research. The Science of the Total Environment 100: 301-318.

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