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Durham University

Solid-State NMR Group

 Solid-State NMR Group

Research interests

2H MAS NMR spectrum of a finasteride solvate

Structure and dynamics in organic solids

Solid-state NMR is often an invaluable complement to diffraction-based methods for the characterisation of crystalline solids. This is particularly important for pharmaceutical systems, where the solid forms (polymorphs) and transformations between them must be fully understood. 13C NMR spectra readily distinguish between different solid forms, including amorphous forms lacking long-range ordering. We have a strong track record of collaboration with various pharmaceutical companies (e.g. AstraZeneca, GlaxoSmithKline, Sanofi-Aventis) for developing methods for characterising structure and dynamics in molecular organic solids. Current systems of interest include a range of solvate materials, looking in particular at the changes associated with desolvation, using a combination of 13C NMR to follow overall structural changes and 2H NMR to probe the solvent and its dynamics.

17O Exchange Spectroscopy (EXSY) on ZrW2O8

Structure and dynamics in inorganic systems

In joint work with the group of Prof. John Evans, we apply solid-state NMR of the study of inorganic framework materials. Characterisation of the structure of these materials by (powder) diffraction techniques alone is difficult, but combining the local information on structure and dynamics from multi-nuclear NMR (e.g. 17O, 31P, 183W) with the long-range structural information from diffraction studies, provide a much fuller understanding of these complex materials. A recent project has used 17O NMR to study the dynamics of oxygen motion in ZrW2O8: solid-state NMR is only technique that allows to both quantify the dynamics and identify its chemical nature. We are currently exploring how solid-state NMR, powder XRD and first principles calculations can be fully integrated to solve increasingly complex structural problems.

For more information contact: Paul Hodgkinson

S. E. Lister, A. Soleilhavoup, R. L. Withers, P. Hodgkinson and J. S. O. Evans, Inorg. Chem. 49 2290 (2010)
M. R. Hampson, J. S. O. Evans and P. Hodgkinson, J. Am. Chem. Soc. 127 15175 (2005)

Theoretical development

There are some important questions in solid-state NMR that are still unresolved e.g. what resolution can we hope to achieve in 1H NMR of solids? Very fast sample spinning (spin rates >60 kHz) allows us to obtain modest resolution from this highly-important nucleus. Our understanding of 1H NMR decoupling in the 13C NMR of solids is correspondingly poor. Unfortunately a corresponding theoretical description is very difficult: the dynamics of multiply interacting magnetic nuclei are complex and often intractable. We are developing novel simulation techniques which allow us to simulate what happens in real solids. In collaboration with other NMR groups (notably at Warwick and Lyon), we are combining these “first principles” numerical simulation with careful experimentation to address fundamental problems in solid-state NMR.


Refer to the recent publications pages for links to recent publications, many of which are now freely available through Open Access.

UK researchers interested to know how solid-state NMR may be useful in their own research can visit the Service information web pages or contact the Service directly.

Prospective PhD or postdoctoral applicants can find more information here.

Contact Details

Solid-State NMR Group
c/o Dr Paul Hodgkinson
Department of Chemistry
Durham University
South Road
Durham DH1 3LE
Solid-State NMR: Basic Principles

Introductory text on solid-state NMR from the Durham NMR group!

Edited volume: Modern Methods in Solid State NMR