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Animal Cells and Systems

A research group of the Department of Biosciences.

We are a grouping of animal biologists working on a range of fundamental biological questions, most of which underpin biomedical interests relevant to the bioeconomy.

Our research ranges from the subcellular level to the whole animal system and is divided into three thematic areas:

Mechanisms of development and ageing - including stem cell biology and age related disease

Cell to system organization and function – focusing on the cytoskeleton, membrane biology and signalling from subcellular to whole animal systems

Cell and tissue biotechnology – incorporating tissue engineering, development and application of in vitro models and biomarkers of health and disease

As a group our fundamental strengths are in basic bioscience and biotechnology using a variety of platform technologies from tissue culture to model organisms. We develop and use a range of state-of-the-art technologies including advanced bioimaging, omics-based approaches and computational strategies. Through interdisciplinary research we have and encourage strong links with other science and medical disciplines within our faculty and with external national and international organisations. These include major corporate industries, HE Institutes and NHS Trusts to develop the medical applications of our research and the fundamental knowledge it delivers. This enables us to realise the value and impact of our fundamental research in underpinning advances for the health and wellbeing of our society.

Academic Members: Prof Carrie A. Ambler, Dr Daphne Bazopoulou, Dr Adam Benham, Dr P Chazot, Dr Rebecca Clark, Dr Vincent Croset, Dr Tim Davies, Dr David Doupe, Dr Martin Goldberg, Prof Colin Jahoda, Dr Akis (Iakowos) Karakesisoglou, Dr Arto Maatta, Prof Stefan Przyborski, Dr S Pyner, Prof Roy Andrew Quinlan, Dr Olena Riabinina, Dr David Weinkove

Affiliates: Dr Martin Schröder, Dr Sushma Grellscheid, Prof Paul Denny

Staff

Academic Staff

Uncategorised

Dr N Hole

Publications by staff in this group

Journal Article

Redhai, S., Pilgrim, C., Gaspar, P., Giesen, L. van, Lopes, T., Riabinina, O., Grenier, T., Milona, A., Chanana, B., Swadling, J.B., Wang, Y.-F., Dahalan, F., Yuan, M., Wilsch-Brauninger, M., Lin, W.-H., Dennison, N., Capriotti, P., Lawniczak, M. K. N., Baines, R. A., Warnecke, T., Windbichler, N., Leulier, F., Bellono, N. W. & Miguel-Aliaga, I. (2020). An intestinal zinc sensor regulates food intake and developmental growth. Nature 580(7802): 263-268.
Shenton, F.C., Campbell, T., Jones, J.F.X. & Pyner, S. (2020). Distribution and morphology of sensory and autonomic fibres in the subendocardial plexus of the rat heart. Journal of Anatomy
Chisholm, David, Lamb, Rebecca, Pallett, Tommy, Affleck, Valerie, Holden, Claire, Marrison, Joanne, O'Toole, Peter, Ashton, Peter, Newling, Katherine, Steffen, Andreas, Nelson, Amanda, Mahler, Christoph, Valentine, Roy, Blacker, Thomas, Bain, Angus John, Girkin, John M, Marder, Todd B, Whiting, Andrew & Ambler, Carrie A (2019). Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene. Chemical Science 10(17): 4673-4683.
Johnson, Simeon, Cowley, Kevin, Hawkins, Timothy J. & Määttä, Arto (2019). Pulling force deforms hair follicle root sheath nuclei and surrounding dermal collagen matrix differently at infundibulum, isthmus and suprabulbar regions. Experimental Dermatology 28(7): 862-866.
Afify, A., Betz, J. F., Riabinina, O., Lahondere, C. & Potter, C. J. (2019). Commonly Used Insect Repellents Hide Human Odors from Anopheles Mosquitoes. Current Biology 29(21): 3669-3680.
Worfolk, JC, Bell, S, Simpson, LD, Carne, NA, Francis, SL, Engelbertsen, V, Brown, AP, Walker, J, Viswanath, YK & Benham, AM (2019). Elucidation of the AGR2 interactome in esophageal adenocarcinoma cells identifies a redox sensitive chaperone hub for the quality control of MUC-5AC. Antioxidants & Redox Signaling 31(15): 1117-1132.
Pini, Alessandro, Grange, Cristina, Veglia, Eleonora, Argenziano, Monica, Cavalli, Roberta, Guasti, Daniele, Calosi, Laura, Ghè, Corrado, Solarino, Roberto, Thurmond, Robin L., Camussi, Giovanni, Chazot, Paul L. & Rosa, Arianna Carolina (2018). Histamine H 4 receptor antagonism prevents the progression of diabetic nephropathy in male DBA2/J mice. Pharmacological Research 128: 18-28.
Doupé, D.P., Marshall, O.J, Dayton, H., Brand, A.H. & Perrimon, N. (2018). Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals. Proceedings of the National Academy of Sciences 115(48): 12218-12223.
Davies, Tim, Kim, Han X, Romano Spica, Natalia, Lesea-Pringle, Benjamin J, Dumont, Julien, Shirasu-Hiza, Mimi & Canman, Julie C (2018). Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity. eLife 7: e36204.
Hirsch, Sophia M., Sundaramoorthy, Sriramkumar, Davies, Tim, Zhuravlev, Yelena, Waters, Jennifer C., Shirasu-Hiza, Mimi, Dumont, Julien & Canman, Julie C. (2018). FLIRT: fast local infrared thermogenetics for subcellular control of protein function. Nature Methods 15(11): 921-923.
Ricci, M., Quinlan, R. A. & Voïtchovsky, K. (2017). Sub-nanometre mapping of the aquaporin-water interface with multifrequency atomic force microscopy. Soft Matter 13(1): 187-195.
Sharma, S., Conover, G., Elliott, J.E., Perng, M.D., Herrmann, H. & Quinlan, R.A. (2017). αB-crystallin is a sensor for assembly intermediates and for the subunit topology of desmin intermediate filaments. Cell Stress and Chaperones 22(4): 613-626.
Resnik-Docampo, Martin, Koehler, Christopher L., Clark, Rebecca I., Schinaman, Joseph M., Sauer, Vivien, Wong, Daniel M., Lewis, Sophia, D’Alterio, Cecilia, Walker, David W. & Jones, D. Leanne (2017). Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis. Nature Cell Biology 19(1): 52-59.
Cliffe, Adam, Doupé, David P., Sung, HsinHo, Lim, Isaac Kok Hwee, Ong, Kok Haur, Cheng, Li & Yu, Weimiao (2017). Quantitative 3D analysis of complex single border cell behaviors in coordinated collective cell migration. Nature Communications 8(1): 14905.
Quinlan, R.A., Schwartz, N., Windoffer, R., Richardson, C., Hawkins, T., Broussard, J.A., Green, K.J. & Leube, R. (2017). A rim-and-spoke hypothesis to explain the biomechanical roles for cytoplasmic intermediate filament networks. Journal of Cell Science 130(20): 3437-3445.
Rapisarda, Valentina, Malashchuk, Igor, Asamaowei, Inemo E., Poterlowicz, Krzysztof, Fessing, Michael Y., Sharov, Andrey A., Karakesisoglou, Iakowos, Botchkarev, Vladimir A. & Mardaryev, Andrei (2017). p63 transcription factor regulates nuclear shape and expression of nuclear envelope-associated genes in epidermal keratinocytes. Journal of Investigative Dermatology 137(10): 2157-2167.
Virk, B., Jia, J., Maynard, C.A., Raimundo, A., Lefebvre, J., Richards, S.A., Chetina, N., Liang, Y., Helliwell, N., Cipinska, M. & Weinkove, D. (2016). Folate acts in E. coli to accelerate C. elegans aging independently of bacterial biosynthesis. Cell Reports 14(7): 1611-1620.
Ciechomska, M., O'Reilly, S., Przyborski, S., Oakley, F., Bogunia-Kubik, K. & van Laar, J.M. (2016). Histone demethylation and toll‐like receptor 8–dependent cross‐talk in monocytes promotes transdifferentiation of fibroblasts in systemic sclerosis via Fra‐2. Arthritis & Rheumatology 68(6): 1493-1504.
Li, Z., Hodgkinson, T., Gothard, E.J., Boroumand, S., Lamb, R., Cummins, I., Narang, P., Sawtell, A., Coles, J., Leonov, G., Reboldi, A., Buckley, C.D., Cupedo, T., Siebel, C., Bayat, A., Coles, M.C. & Ambler, C.A. (2016). Epidermal Notch1 recruits RORgamma+ group 3 innate lymphoid cells to orchestrate normal skin repair. Nature Communications 7: 11394.
Riabinina, O., Task, D., Marr, E., Lin, C.-C., Alford, R., O'Brochta, D. A. & Potter, C. J. (2016). Organization of olfactory centres in the malaria mosquito Anopheles gambiae. Nature Communications 7: 13010.
Kataky, R., Hadden, J.H.L., Coleman, K.S., Ntola, C.N.M., Chowdhury, M., Duckworth, A.R., Dobson, B.P., Campos, R., Pyner, S. & Shenton F. (2015). Graphene oxide nanocapsules within silanized hydrogels suitable for electrochemical pseudocapacitors. Chemical Communications 51(51): 10345-10348.
Clark, R. I., Salazar, A., Yamada, R., Fitz-Gibbon, S., Morselli, M., Alcaraz, J., Rana, A., Rera, M., Pellegrini, M., Ja, W. W. & Walker, D. W. (2015). Distinct shifts in microbiota composition during Drosophila aging impair intestinal function and drive mortality. Cell Reports 12(10): 1656-1667.
Hill, D.S., Robinson, N.D.P., Caley, M.P., Chen, M., O'Toole, E.A., Armstrong, J.L., Przyborski, S. & Lovat, P.E. (2015). A novel fully-humanised 3D skin equivalent to model early melanoma invasion. Molecular Cancer Therapeutics 14(11): 2665-2673.
Wu, J.J., Wu, W., Tholozan, F.M., Saunter, C.D., Girkin, J.M. & Quinlan, R.A. (2015). A dimensionless ordered pull-through model of the mammalian lens epithelium evidences scaling across species and explains the age-dependent changes in cell density in the human lens. Journal of The Royal Society Interface 12(108): 20150391.
Palmer, S.E., Smaczynska-de Rooij, I.I., Marklew, C.J., Allwood, E.G., Mishra, R., Johnson, S., Goldberg, M.W. & Ayscough, K.R. (2015). A dynamin-actin interaction is required for vesicle scission during endocytosis in yeast. Current Biology 25(7): 868-878.
Quinlan, R.A. (2015). A new dawn for cataracts. Science 350(6261): 636-637.
Gao, X.J., Riabinina, O., Li, J., Potter, C. J., Clandinin, T. R. & Luo, L. (2015). A transcriptional reporter of intracellular Ca2+ in Drosophila. Nature Neuroscience 18(6): 917-925.
Riabinina, O., Luginbuhl, D., Marr, E., Liu, S., Wu, M. N., Luo, L. & Potter, C. J. (2015). Improved and expanded Q-system reagents for genetic manipulations. Nature Methods 12(3): 219-222.
Davies, Tim, Kodera, Noriyuki, Kaminski Schierle, Gabriele S., Rees, Eric, Erdelyi, Miklos, Kaminski, Clemens F., Ando, Toshio & Mishima, Masanori (2015). CYK4 Promotes Antiparallel Microtubule Bundling by Optimizing MKLP1 Neck Conformation. PLOS Biology 13(4): e1002121.
Fiserova, J., Spink, M., Richards, S.A., Saunter, C. & Goldberg, M.W. (2014). Entry into the nuclear pore complex is controlled by a cytoplasmic exclusion zone containing dynamic GLFG-repeat nucleoporin domains. Journal of Cell Science 127: 124-136.
Cartwright, S. & Karakesisoglou, I. (2014). Nesprins in health and disease. Seminars in Cell and Developmental Biology 29: 169-179.
Defour, A., van der Meulen, J.H., Bhat, R., Bigot, A., Bashir, R., Nagaraju, K. & Jaiswal, J.K. (2014). Dysferlin regulates cell membrane repair by facilitating injury-triggered acid sphingomyelinase secretion. Cell Death and Disease 5(6): e1306.