Biomolecular Interactions

A research group of the Department of Biosciences.

Bioscience Embedded within Chemistry.

Biomolecular interactions, including contacts between biological macromolecules (protein/protein or protein/nucleic acids) and protein-ligand interactions are central to biochemistry. This grouping addresses fundamental questions concerning, for example, the recognition of DNA by bacterial proteins, the biophysical basis of allostery and the supply of metals to proteins. Multiple projects aim to identify targets for new antimicrobial (and antiviral) compounds and typically exploit a wide range of chemical, biochemical, and biophysical methods.

More than half of the members of the group are located in embedded biology laboratories within the Department of Chemistry and PIs have close interactions with the Bioactive Chemistry and Synthesis grouping in chemistry.

Group Coordinator: Dr Paul Denny

Academic Staff: Dr Tim R Blower, Prof Martin Cann, Dr Peter Chivers, Dr Paul Denny, Dr Karrera Djoko, Dr Sushma Grellschied, Dr Ehmke Pohl, Prof. Nigel Robinson, Dr Martin Schröder, Dr Gary Sharples, Prof A Walmsley.

Affiliates: Dr Adam Benham, Dr P Chazot, Dr Tony Fawcett, Professor John A. Gatehouse, Dr Martin Goldberg, Prof Keith Lindsey, Dr J Liu, Dr David Weinkove

Research Areas

• Biomolecular interactions and protein-ligand interactions play a central role in all our research interest

Staff

Academic Staff

• Dr Tim R Blower
• Professor Martin Cann
• Dr Peter Chivers
• Dr Paul Denny
• Dr Karrera Djoko
• Dr Sushma Grellscheid
• Dr Ehmke Pohl
• Prof. Nigel Robinson
• Dr Martin Schröder
• Dr Gary Sharples
• Prof A Walmsley

Publications by staff in this group

Journal Article

• Djoko, Karrera Y., Achard, Maud E. S., Phan, Minh-Duy, Lo, Alvin W., Miraula, Manfredi, Prombhul, Sasiprapa, Hancock, Steven J., Peters, Kate M., Sidjabat, Hanna, Harris, Patrick N., Mitić, Nataša, Walsh, Timothy R., Anderson, Gregory J., Shafer, William M., Paterson, David L., Schenk, Gerhard, McEwan, Alastair G. & Schembri, Mark A. (2018). Copper ions and coordination complexes as novel carbapenem adjuvants. Antimicrobial Agents and Chemotherapy 62(2): e02280-17.
• Townsend, P.D., Dixon, C.H., Slootweg, E.S., Sukarta O.C.A., Yang, A.W.H., Hughes, T.R., Sharples, G.J., Palsson, L.-O., Takken, F.L.W., Goverse, A. & Cann, M.J. (2018). The intracellular immune receptor Rx1 regulates the DNA-binding activity of a Golden2-like transcription factor. The Journal of Biological Chemistry 293(9): 3218-3233.
• Linthwaite, V.L., Janus, J.M., Brown, A.P., Wong-Pascua, D., O’Donoghue, A.C., Porter, A., Treumann, A., Hodgson, D.R.W. & Cann, M.J. (2018). The identification of carbon dioxide mediated protein post-translational modifications. Nature Communications 9: 3092.
• Huang, H-T., Bobst, C. E., Iwig, J. S., Chivers, P. T., Kaltashov, I. & Maroney, M. J. (2018). Co(II) and Ni(II) binding of the Escherichia coli transcriptional repressor RcnR orders its N-terminus, alters helix dynamics, and reduces DNA affinity. Journal of Biological Chemistry 293(1): 324-332.
• Foster, A.W., Pernil, R., Patterson, C.J., Scott, A.J.P., Pålsson, L.-O., Pal, R., Cummins, I., Chivers, P.T., Pohl, E. & Robinson, N.J. (2017). A tight tunable range for Ni(II) sensing and buffering in cells. Nature Chemical Biology 13(4): 409-414.
• Osman, Deenah, Foster, Andrew W., Chen, Junjun, Svedaite, Kotryna, Steed, Jonathan W., Lurie-Luke, Elena, Huggins, Thomas G. & Robinson, Nigel J. (2017). Fine control of metal concentrations is necessary for cells to discern zinc from cobalt. Nature Communications 8: 1884.
• Brown, M., Strudwick, N., Suwara, M., Sutcliffe, L. K., Mihai, A. D., Ali, A. A., Watson, J. N. & Schröder, M. (2016). An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response. Journal of Cell Science 129(12): 2317-2328.
• Townsend, P.D., Rodgers, T.L., Glover, L.C., Korhonen, H.J., Richards, S.A., Colwell, L.J., Pohl, E., Wilson, M.R., Hodgson, D.R.W., McLeish, T.C.B. & Cann, M.J. (2015). The role of protein-ligand contacts in allosteric regulation of the Escherichia coli Catabolite Activator Protein. Journal of Biological Chemistry 290(36): 22225-22235.
• Osman, D., Piergentili, C., Chen, J., Chakrabarti, B., Foster, A., Lurie-Luke, E., Huggins, T. & Robinson, N. (2015). Generating a metal-responsive transcriptional regulator to test what confers metal-sensing in cells. Journal of Biological Chemistry 290(32): 19806-19822.
• Fenyk, Stepan, Townsend, Philip D., Dixon, Christopher H., Spies, Gerhard B., de San Eustaquio Campillo, Alba, Slootweg, Erik J., Westerhof, Lotte B., Gawehns, Fleur K.K., Knight, Marc R., Sharples, Gary J., Goverse, Aska, Pålsson, Lars-Olof, Takken, Frank L.W. & Cann, Martin J. (2015). The Potato Nucleotide-Binding Leucine-Rich Repeat (NLR) Immune Receptor Rx1 is a Pathogen Dependent DNA-Deforming Protein. Journal of Biological Chemistry 290(41): 24945-24960.