Dr Max Brown, BSc Hons, PhD
I am a PDRA in the Department of Biosciences. I have ten years of experience as an active researcher in cell biology, focusing on the secretory pathway and more recently mechanobiology, collaborating with engineers and computer scientists.
My current project, in collaboration with industry, combines state of the art imaging techniques with mechanical stretching of mammalian cells. As part of this project, I have used CAD to design and build a user-friendly, microscope-mountable stretching device. In addition to this work, I am investigating collagen trafficking and synthesis through the secretory pathway.
I have been involved in multiple outreach projects from the Durham Science Festival to Parkinson's UK Research Awareness meetings.
I also enjoying creating video and other media to highlight and broaden the audience of my research and work. Click here to see the 2-minute video abstract I created for one of my recent publications
And another video here, which I created for Parkinson's UK to raise awareness of research and the 'Dave the worm' sponsorship scheme:
- Endoplasmic reticulum stress
- Brown, Max, Dainty, Samantha, Strudwick, Natalie, Mihai, Adina D., Watson, Jamie N., Dendooven, Robina, Paton, Adrienne W., Paton, James C. & Schröder, Martin (2020). Endoplasmic reticulum stress causes insulin resistance by inhibiting delivery of newly synthesised insulin receptors to the cell surface. Molecular Biology of the Cell 31(23): 2495-2629.
- Henderson, John, Brown, Max, Horsburgh, Steven, Duffy, Laura, Wilkinson, Sarah, Worrell, Julie, Stratton, Richard & O’Reilly, Steven (2018). Methyl cap binding protein 2: a key epigenetic protein in systemic sclerosis. Rheumatology 58(3): 527.
- Brown, M. & O'Reilly, S. (2018). The immunopathogenesis of fibrosis in systemic sclerosis. Clinical & Experimental Immunology
- Brown, M., Strudwick, N., Suwara, M., Sutcliffe, L. K., Mihai, A. D., Ali, A. A., Watson, J. N. & Schröder, M. (2016). An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response. Journal of Cell Science 129(12): 2317-2328.