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Research

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Prof Keith Lindsey, FLS, FRSB

Head of Department, Professor in the School of Biological and Biomedical Sciences
Head of Department (biosci.headofschool@durham.ac.uk), School of Biological and Biomedical Sciences
Telephone: +44 (0) 191 33 41309

Contact Prof Keith Lindsey (email at keith.lindsey@durham.ac.uk)

Biography

For my first degree I read Botany at St. Catherine's College Oxford, followed by a PhD from Edinburgh University. I carried out post-doc work in Edinburgh and then Rothamsted, before taking up a position as leader of the Plant Molecular Genetics Group at the Leicester Biocentre, and a lectureship at Leicester University (1989). I moved to a Chair in Durham in 1996.

Our research programme is focused on the developmental biology of plants, and in particular on molecular control mechanisms in embryogenesis and root development. We make use of a range of techniques in functional genomics, and exploit the many advantages of Arabidopsis thaliana as a model experimental organism. We developed promoter trap insertional mutagenesis in a forward genetics approach to identify genes required for correct embryogenesis and root development, and also use reverse genetics techniques (RNAi, identification of gene knockouts) to characterize the functions of genes identified by cDNA cloning. More recently, we developed laser-capture microdissection in combination with expression profiling to identify transcription factors and signalling pathway components expressed in subdomains of developing embryos, and in roots. A current feature of our work is the development of predictive mathematical models to describe gene-hormone signalling network interactions, with Junli Liu and with Michael Goldstein and Ian Vernon in the Department of Mathematical Sciences. An integrating theme is that of polarity - in the establishment of the apical-basal axis of the embryo and of the root axis. We also have a number of other collaborative projects, both with other academic laboratories and with industry, which build upon expertise and materials developed in our basic science programmes. These include the development of novel resistance mechanisms to plant-parasitic nematodes, in collaboration with several European laboratories; projects on cotton with Prof. Xianlong Zhang at Huazhong Agricultural University, China, where I have been appointed Visiting Professor; and the development of a spin-out company, Creative Gene Technology Ltd., a collaborative venture with Prof. Toni Slabas.

I am an Editor of the journal New Phytologist and Chair of the Board of Trustees for the New Phytologist Trust. I was until recently a member BBSRC Council, the body that determines policy, priorities and strategy for BBSRC; Chair of BBSRC Appointments Board; and a member of the Defra Advisory Committee on Releases to the Environment (ACRE), which advises Government Ministers on GM and related issues. I am former President and Chair of Council of the Society for Experimental Biology. Some of my publications are listed below.

Research Groups

School of Biological and Biomedical Sciences

Publications

Authored book

  • K. Lindsey & M.G.K. Jones (1989). Plant Biotechnology in Agriculture. Milton Keynes: Open University Press.

Chapter in book

  • Mehdi, S., Mudge, A., Rowe, J., Liu, J., Topping, J.F. & Lindsey, K. (2016). The POLARIS Peptide: Role in Hormone Signalling and Root Growth. In Annual Plant Reviews: Peptide Signals in Plants. Huffaker, A. & Pearce, G. Wiley-Blackwell. in press.
  • Fonseka, D.L.C.K., Yang, X., Mudge, A., Topping, J.F. & Lindsey, K. (2013). Embryogenesis in Arabidopsis: Signalling, Genes and the Control of Identity. In Seed Genomics. Becraft, P.W. Wiley-Blackwell. 21-42.
  • Lindsey, K., Mehdi, S., Casson, S.A., Mudge, A.J., Topping, J.F. & Liu, J. (2013). POLARIS. In The Handbook of Biologically Active Peptides, 2nd Edition. Kastin, A.J. Academic Press. 40-45.
  • Casson, S.A., Spencer, M.W.B. & Lindsey, K. (2007). Laser-capture microdissection to study global transcriptional changes during plant embryogenesis. In Methods in Molecular Biology: Plant Embryogenesis Methods and Protocols. Suarez, M.F. & Bozhkov, P. New Jersey: Harwood. 427: 111-120.
  • Lindsey, K., Casson, S.A. & Chilley, P.M. (2006). The POLARIS peptide. In The Handbook Of Biologically Active Peptides. Kastin, A.J. Academic Press. 23-27.
  • Lindsey, K. & Wei, W. (2000). Arabidopsis tissue culture, transformation and transient gene expression. In Arabidopsis: A Practical Approach. Wilson, Z. Oxford: Oxford University Press. 123-141.
  • Gheysen, G., Abad, P., Bleve, T., Blok, V., Fenoll, C., Gatehouse, J., Grundler, F., Lindsey, K., Ohl, S., Sagen, K., Shields, R. & Helder, H. (2000). Concerted efforts to develop handles for plant parasitic nematode control. In Phytosphere ’99 – Highlights in European Biotechnology. Developments in Plant Genetics and Breeding 6. de Vries, G.E. & Metzlaff, K. Elsevier. 159-167.

Edited book

Journal Article

Supervises